Increased Levels of Anti- Antibodies During Hospital Admission in Septic Patients.

Background/objectives: In a previous study, we described elevated anti- IgG levels in septic patients in relation to disease severity. In this study, our objective was to analyze the evolution of anti- immunoglobulins in septic patients during hospital admission and their association with αβ and γδ T cell subsets.

Methods: We recruited 80 subjects: 40 patients with sepsis and 40 controls.

SARS-CoV-2 transmission risk screening for safer social events: a non-randomised controlled study.

There is an ongoing debate on the implementation of the COVID-19 passport throughout Europe. We sought to build and test a feasible prevention strategy to ensure low SARS-CoV transmission risk in public events. We conducted a non-randomised controlled study.

Designing pandemic-resilient voting systems.

The 2020 general election occurred while many parts of the nation were under emergency orders related to the COVID-19 pandemic. This led to new requirements and considerations for voting systems. We introduce a model of the voting process to capture pandemic-related changes.

Impact of a community-policing initiative promoting substance use disorder treatment over criminal charges on arrest recidivism.

Background: Overdose deaths, addiction, and drug-related crime have increased in the United States over the past decade. Treatment improves outcomes, including reducing crime, but few individuals with addiction receive treatment. Here, we determine whether the Madison Addiction Recovery Initiative (MARI), a community policing program implemented by the City of Madison (Wisconsin) Police Department (MPD) that diverts adults who committed a non-violent, drug use-related crime from criminal prosecution to addiction treatment, reduces the risk of recidivism (i.

A Robust Approach for Mitigating Risks in Cyber Supply Chains.

In recent years, there have been growing concerns regarding risks in federal information technology (IT) supply chains in the United States that protect cyber infrastructure. A critical need faced by decisionmakers is to prioritize investment in security mitigations to maximally reduce risks in IT supply chains. We extend existing stochastic expected budgeted maximum multiple coverage models that identify "good" solutions on average that may be unacceptable in certain circumstances.

An expected coverage model with a cutoff priority queue.

Emergency medical services provide immediate care to patients with various types of needs. When the system is congested, the response to urgent emergency calls can be delayed. To address this issue, we propose a spatial Hypercube approximation model with a cutoff priority queue that estimates performance measures for a system where some servers are reserved exclusively for high priority calls when the system is congested.

Automated Device for Asynchronous Extraction of RNA, DNA, or Protein Biomarkers from Surrogate Patient Samples.

Many biomarker-based diagnostic methods are inhibited by nontarget molecules in patient samples, necessitating biomarker extraction before detection. We have developed a simple device that purifies RNA, DNA, or protein biomarkers from complex biological samples without robotics or fluid pumping. The device design is based on functionalized magnetic beads, which capture biomarkers and remove background biomolecules by magnetically transferring the beads through processing solutions arrayed within small-diameter tubing.

Comparison of three magnetic bead surface functionalities for RNA extraction and detection.

Magnetic beads are convenient for extracting nucleic acid biomarkers from biological samples prior to molecular detection. These beads are available with a variety of surface functionalities designed to capture particular subsets of RNA. We hypothesized that bead surface functionality affects binding kinetics, processing simplicity, and compatibility with molecular detection strategies.

Transient global amnesia after dobutamine--atropine stress echocardiography.

Dobutamine-atropine stress echocardiography is a useful and relatively safe test for coronary artery disease assessment. However, possible complications should be recognized. We describe a case of transient global amnesia in a woman who underwent a standard-protocol dobutamine-atropine stress echocardiogram for coronary ischaemia detection, after having complained about chest pain.