The Global Regulatory Cyclic AMP Receptor Protein (CRP) Controls Multifactorial Fluoroquinolone Susceptibility in Salmonella enterica Serovar Typhimurium.

Fluoroquinolone antibiotics are prescribed for the treatment of infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroquinolones. A Δ mutation was synergistic with the primary fluoroquinolone resistance allele , thus able to contribute to clinically relevant resistance.

A resilience-oriented treatment for posttraumatic stress disorder: results of a preliminary randomized clinical trial.

This preliminary randomized trial examined the effect of a resilience-oriented intervention for posttraumatic stress disorder (PTSD) versus a waitlist control on anxiety and depressive symptoms, positive emotional health, and cognitive performance in 39 veterans with a variety of traumatic exposures. From pre- to posttreatment, the intervention but not the control group showed improvements that were large in magnitude for affective symptoms and positive emotional health (ds = 0.73-1.