Evaluation of the epidemiology of peanut allergy in the United Kingdom.

: To describe the epidemiology of peanut allergy (PA) in the UK over the last three decades.: PA patients were identified from the Clinical Practice Research Datalink between 1987 and 2015. Incidence and prevalence of PA were compared between 2000 and 2015.

Evaluation of the healthcare resource use and the related financial costs of managing peanut allergy in the United Kingdom.

: We aimed to estimate the resource use and associated costs for patients with peanut allergy (PA) compared to matched controls. : This was a retrospective cohort study using data from the UK Clinical Practice Research Datalink and Hospital Episode Statistics. PA patients were matched to two control cohorts: the first (simple-matched) were matched 1:1 on year of birth, general practice, gender and registration year.

Hospital admissions for severe infections in people with chronic kidney disease in relation to renal disease severity and diabetes status.

Background: Immunosuppressive agents are being investigated for the treatment of chronic kidney disease (CKD) but may increase risk of infection. This was a retrospective observational study intended to evaluate the risk of hospitalized infection in patients with CKD, by estimated glomerular filtration rate (eGFR) and proteinuria status, aiming to identify the most appropriate disease stage for immunosuppressive intervention.

Methods: Routine UK primary-care and linked secondary-care data were extracted from the Clinical Practice Research Datalink.

Non-Response to Antibiotic Treatment in Adolescents for Four Common Infections in UK Primary Care 1991-2012: A Retrospective, Longitudinal Study.

We studied non-response rates to antibiotics in the under-reported subgroup of adolescents aged 12 to 17 years old, using standardised criteria representing antibiotic treatment failure. Routine, primary care data from the UK Clinical Practice Research Datalink (CPRD) were used. Annual, non-response rates by antibiotics and by indication were determined.

The impact of comorbid cannabis and methamphetamine use on mental health among regular ecstasy users.

Objective: Residual effects of ecstasy use induce neurotransmitter changes that make it biologically plausible that extended use of the drug may induce psychological distress. However, there has been only mixed support for this in the literature. The presence of polysubstance use is a confounding factor.

Water potential of standing-dead shoots of an intertidal grass.

Dead stems and leaves of smooth cordgrass (Spartina alterniflora Loisel.) undergo substantial fungal decay in the standing position. We conducted a series of experiments to determine the probable range of water availabilities that cordgrass-fungal decomposers experience; we determined the effects of duration of wetting and drying, site on shoots, leaching of osmotica, and stage of decomposition on water potential (ψ) of cordgrass shoots.