Publications by authors named "Laura A Nucci"
Background And Objectives: Sepsis is a complex disease that is characterized by activation and inhibition of different cell signaling pathways according to the disease stage. Here, we evaluated genes involved in the TLR signaling pathway, oxidative phosphorylation and oxidative metabolism, aiming to assess their interactions and resulting cell functions and pathways that are disturbed in septic patients.
Materials And Methods: Blood samples were obtained from 16 patients with sepsis secondary to community acquired pneumonia at admission (D0), and after 7 days (D7, N = 10) of therapy.
Article Synopsis
- The study explores the inflammatory response in sepsis, focusing on the complex interactions between different signaling pathways and the incomplete understanding of the syndrome so far.
- By utilizing whole-genome expression profiling on mononuclear cells from septic patients with community-acquired pneumonia, the research aims to identify genes linked to recovery and infection defense.
- The findings, including clinical details and data analysis methods, are detailed, and the results are available in the Gene Expression Omnibus (GEO) database, highlighting gene expression patterns that could inform patient outcomes.
Mechanisms governing the inflammatory response during sepsis have been shown to be complex, involving cross-talk between diverse signaling pathways. Current knowledge regarding the mechanisms underlying sepsis provides an incomplete picture of the syndrome, justifying additional efforts to understand this condition. Microarray-based expression profiling is a powerful approach for the investigation of complex clinical conditions such as sepsis.
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