Natural history of GM1 gangliosidosis-Retrospective cohort study of 61 French patients from 1998 to 2019.

GM1 gangliosidosis is a rare lysosomal storage disorder associated with β-galactosidase enzyme deficiency. There are three types of GM1 gangliosidosis based on age of symptom onset, which correlate with disease severity. In 2019, we performed a retrospective multicentric study including all patients diagnosed with GM1 gangliosidosis in France since 1998.

Focal epilepsy due to de novo SCN1A mutation.

Objective: Our aim was to identify patients with SCN1A-related epilepsy with a phenotype of pure focal epilepsy.

Methods: We conducted a retrospective study and a systematic review in Pubmed to identify patients with focal epilepsy associated with SCN1A pathogenic variants.

Results: We found three patients among 1,191 in our rare epilepsy database in 2017.

Relation between Ejection Mechanism and Ion Abundance in the Electric Double Layer of Droplets.

Charged droplets have been associated with distinct chemical reactivity. It is assumed that the composition of the surface layer plays a critical role in enhancing the reaction rates in the droplets relative to their bulk solution counterparts. We use atomistic modeling to relate the localization of ions in the surface layer to their ejection propensity.

The effects of acute stretching on hamstring muscle fatigue and perceived exertion.

The aim of this study was to examine the effects of an acute stretching regime on hamstring muscle fatigue and rating of perceived exertion during a dynamic, sub-maximal bout of resistance exercise. Sixteen healthy males (age 25.7 +/- 4.

A comparison of intraoperative morphine sulfate and methadone hydrochloride on postoperative visual analogue scale pain scores and narcotic requirements.

Morphine sulfate and methadone hydrochloride exhibit very different half-lives but are described as having an analgesic potency of one. The use of a drug like methadone may provide prolonged and constant analgesia in the perioperative setting. This double-blinded investigation used methadone and morphine intraoperatively and measured pain scores and narcotic requirements in the first 24 hours postoperatively.

Community recovery after storm damage: a case of facilitation in primary succession.

Manipulations of early arriving, fast-growing algal stands, which appeared soon after a severe storm denuded a Southern California marine reef habiatat, indicated that the dense cover protected newly settled kelp plants from excessive damage by grazing fishes. This is an example of refuge facilitation in primary succession after a major natural disturbance, a mechanism that may contribute substantially to the regeneration of a kelp forest.