Application of CFD modelling at a full-scale ozonation plant for the removal of micropollutants from secondary effluent.

Since November 2009, Germany's first full-scale ozonation plant for tertiary treatment of secondary effluent is in continuous operation. A kinetic model was developed and combined with the commercial computational fluid dynamics (CFD) software ANSYS(®) CFX(®) to simulate the removal of micropollutants from secondary effluents. Input data like reaction rate constants and initial concentrations of bulk components of the effluent organic matter (EfOM) were derived from experimental batch tests.

Partial dopamine agonists in schizophrenia.

The emergence of partial dopamine agonists reinforces the argument for the dopamine hypothesis of schizophrenia. Aripiprazole (Abilify) is the first of these compounds for the treatment of schizophrenia to be launched in the UK. Aripiprazole has a promising efficacy and favourable tolerability profile that suggests it has a significant role to play in the management of schizophrenia.

Amisulpride augmentation of clozapine: an open non-randomized study in patients with schizophrenia partially responsive to clozapine.

Objective: Treatment options are very limited for individuals with schizophrenia resistant to clozapine. We tested the hypothesis that amisulpride augmentation would lead to an improvement in these patients.

Method: This was an open non-randomized study.

Clozapine.

Clozapine is an atypical agent for intractable schizophrenia which was introduced into the UK at the beginning of 1990. Its lack of extrapyramidal side effects and its action on negative symptoms single it out from conventional neuroleptics. This article describes the drug's development/special monitoring and dispensing arrangements, and gives advice on how it can best be utilized.

Acute functional psychoses: treatment with zuclopenthixol dihydrochloride ('Clopixol') tablets.

An assessment of the efficacy and tolerability of zuclopenthixol dihydrochloride tablets in the treatment of acute psychotic episodes was undertaken in 63 patients in an open multi-centre study. Most patients prior to entering the study had received other neuroleptic drugs, but with inadequate effect. During the 10-week study, the dosage of zuclopenthixol dihydrochloride tablets could be adjusted to obtain optimum clinical benefit.