Expression of angiotensin II receptor type 1 is reduced in advanced rat liver fibrosis.

In this study, we assessed the hypothesis that the expression of angiotensin II receptor type 1 (AGTR1) in liver tissue changes with increasing fibrosis, which would influence the antifibrotic efficacy of AGTR1 blockers. Rats were treated with candesartancilexetil (CAN) initiated 8 or 15 days after bile duct occlusion (BDO). Four weeks after BDO, AGTR1 mRNA and protein were decreased compared to those in sham-operated animals depending on the amount of fibrosis.

Acute saline infusion induces extracellular acidification and activation of the Na+/H+ exchanger in man.

The effect of acute expansion of the extracellular fluid volume (ECV) with isotonic (0.9%) saline on the activity of the lymphocyte Na+/H+ antiport (NHE) was studied in a total of 18 healthy volunteers. Saline was infused at a constant rate so that 4 mmol kg-1 b.

Evaluation of brain tissue O2 supply based on results of PO2 measurements with needle and surface microelectrodes.

Tissue PO2 distribution was measured in rat cerebral cortex during arterial normoxia and arterial hypoxia. The study was designed to examine the relationship between the PO2 histograms determined with surface electrodes in the superficial cortical cells and with needle electrodes in the cortical laminae below. Under normoxic as well as under hypoxic conditions the PO2 distributions of the compared brain regions were in close agreement.