Identifying Key Drivers in the Pathogenesis of Martorell Hypertensive Ischaemic Leg Ulcer: A Comparative Analysis with Chronic Venous Leg Ulcer.

Martorell hypertensive ischaemic leg ulcer (Martorell HYTILU) is a rare but significant cause of distal leg ulcers. Although hypertension and diabetes are known factors in its development, the precise pathogenesis of Martorell HYTILU remains elusive. To reach a better understanding of Martorell HYTILU, transcriptomic analysis was conducted through RNA sequencing and immunohistochemical comparison of Martorell HYTILU (n = 17) with chronic venous ulcers (n = 4) and healthy skin (n = 4).

East Asian summer monsoon delivers large abundances of very-short-lived organic chlorine substances to the lower stratosphere.

Deep convection in the Asian summer monsoon is a significant transport process for lifting pollutants from the planetary boundary layer to the tropopause level. This process enables efficient injection into the stratosphere of reactive species such as chlorinated very-short-lived substances (Cl-VSLSs) that deplete ozone. Past studies of convective transport associated with the Asian summer monsoon have focused mostly on the south Asian summer monsoon.

The genetic landscape and clinical implication of pediatric Moyamoya angiopathy in an international cohort.

Pediatric Moyamoya Angiopathy (MMA) is a progressive intracranial occlusive arteriopathy that represents a leading cause of transient ischemic attacks and strokes in childhood. Despite this, up to now no large, exclusively pediatric MMA cohort has been subjected to systematic genetic investigation. In this study, we performed molecular karyotyping, exome sequencing and automated structural assessment of missense variants on a series of 88 pediatric MMA patients and correlated genetic, angiographic and clinical (stroke burden) findings.

Functional and Immunological Studies Revealed a Second Superantigen Toxin in Staphylococcal Enterotoxin C Producing Strains.

is a human and animal pathogen as well as a commensal bacterium. It can be a causative agent of severe, life-threatening infections with high mortality, e.g.

Sexual Behavior, Desire, and Psychosexual Experience in Gynephilic and Androphilic Trans Women: A Cross-Sectional Multicenter Study.

Background: One of the most prominent etiological theories of gender incongruence in trans women proposes a paraphilic erotic target location error (ie, autogynephilia) as a causal factor in gynephilic (ie, exclusively gynephilic and bisexual) trans women. We hypothesized that a paraphilic erotic target location should manifest itself in various aspects of sexual behavior, solitary and dyadic sexual desire, and psychosexual experience.

Aim: To compare sexual behavior, sexual desire, and psychosexual experience of exclusively gynephilic and bisexual trans women with that of androphilic trans women to explore whether their sexuality differs substantially.

Investigation of East Asian Emissions of CFC-11 Using Atmospheric Observations in Taiwan.

Recent findings of an unexpected slowdown in the decline of CFC-11 mixing ratios in the atmosphere have led to the conclusion that global CFC-11 emissions have increased over the past decade and have been attributed in part to eastern China. This study independently assesses these findings by evaluating enhancements of CFC-11 mixing ratios in air samples collected in Taiwan between 2014 and 2018. Using the NAME (Numerical Atmospheric Modeling Environment) particle dispersion model, we find the likely source of the enhanced CFC-11 observed in Taiwan to be East China.

Integrative East-West Medicine Intervention for Chronic Daily Headache: A Case Report and Care Perspective.

Chronic daily headache is a group of headache syndromes including most commonly chronic migraine and chronic tension-type headache, which often overlap, are complicated by medication overuse and are disabling, costly, and variable responsive to western pharmacotherapeutic interventions. There is growing research and awareness of integrative health approaches and therapies to address patients with chronic headache, yet limited examples of how to deliver this approach. This article reviews a commonly seen challenging case of a patient with overlapping chronic migraine and chronic tension-type headache complicated by medication overuse managed with an integrative east-west medicine intervention.

Interplay of bimolecular and Auger recombination in photoexcited carrier dynamics in silicon nanocrystal/silicon dioxide superlattices.

We report results of investigating carrier recombination in silicon nanocrystal/silicon dioxide superlattices. The superlattices prepared by nitrogen-free plasma enhanced chemical vapour deposition contained layers of silicon nanocrystals. Femtosecond transient transmission optical spectroscopy was used to monitor carrier mechanisms in the samples.

Electrostatic assembly of zwitterionic and amphiphilic supraparticles.

We demonstrate the electrostatic assembly of oppositely charged silica particles into an ensemble of well-defined core-satellite supraparticles, which are a type of patchy particle. To achieve controlled heteroaggregation, we used oppositely charged silica particles with different sizes ranging from 5nm to 150nm at several concentrations. The assembly works best with larger particles, resulting in a fairly low polydispersity and a low amount of bridging between the individual clusters.

Comparison of Patient Health History Questionnaires Used in General Internal and Family Medicine, Integrative Medicine, and Complementary and Alternative Medicine Clinics.

Objectives: Health history questionnaires (HHQs) are a set of self-administered questions completed by patients prior to a clinical encounter. Despite widespread use, minimal research has evaluated the content of HHQs used in general internal medicine and family medicine (GIM/FM), integrative medicine, and complementary and alternative medicine (CAM; chiropractic, naturopathic, and Traditional Chinese Medicine [TCM]) clinics. Integrative medicine and CAM claim greater emphasis on well-being than does GIM/FM.

Can we detect a nonlinear response to temperature in European plant phenology?

Over a large temperature range, the statistical association between spring phenology and temperature is often regarded and treated as a linear function. There are suggestions that a sigmoidal relationship with definite upper and lower limits to leaf unfolding and flowering onset dates might be more realistic. We utilised European plant phenological records provided by the European phenology database PEP725 and gridded monthly mean temperature data for 1951-2012 calculated from the ENSEMBLES data set E-OBS (version 7.

Contact Forces between TiO2 Nanoparticles Governed by an Interplay of Adsorbed Water Layers and Roughness.

Interparticle forces govern the mechanical behavior of granular matter and direct the hierarchical assembling of nanoparticles into supramolecular structures. Understanding how these forces change under different ambient conditions would directly benefit industrial-scale nanoparticle processing units such as filtering and fluidization. Here we rationalize and quantify the contributions of dispersion, capillary, and solvation forces between hydrophilic TiO2 nanoparticles with sub-10 nm diameter and show that the humidity dependence of the interparticle forces is governed by a delicate interplay between the structure of adsorbed water layers and the surface roughness.

Observing the morphology of single-layered embedded silicon nanocrystals by using temperature-stable TEM membranes.

We use high-temperature-stable silicon nitride membranes to investigate single layers of silicon nanocrystal ensembles by energy filtered transmission electron microscopy. The silicon nanocrystals are prepared from the precipitation of a silicon-rich oxynitride layer sandwiched between two SiO2 diffusion barriers and subjected to a high-temperature annealing. We find that such single layers are very sensitive to the annealing parameters and may lead to a significant loss of excess silicon.

Structural parameters effect on the electrical and electroluminescence properties of silicon nanocrystals/SiO2 superlattices.

The effect of the oxide barrier thickness (tSiO2) reduction and the Si excess ([Si]exc) increase on the electrical and electroluminescence (EL) properties of Si-rich oxynitride (SRON)/SiO2 superlattices (SLs) is investigated. The active layers of the metal-oxide-semiconductor devices were fabricated by alternated deposition of SRON and SiO2 layers on top of a Si substrate. The precipitation of the Si excess and thus formation of Si nanocrystals (NCs) within the SRON layers was achieved after an annealing treatment at 1150 °C.

From observations to experiments in phenology research: investigating climate change impacts on trees and shrubs using dormant twigs.

Background And Aims: Climate change is advancing the leaf-out times of many plant species and mostly extending the growing season in temperate ecosystems. Laboratory experiments using twig cuttings from woody plant species present an affordable, easily replicated approach to investigate the relative importance of factors such as winter chilling, photoperiod, spring warming and frost tolerance on the leafing-out times of plant communities. This Viewpoint article demonstrates how the results of these experiments deepen our understanding beyond what is possible via analyses of remote sensing and field observation data, and can be used to improve climate change forecasts of shifts in phenology, ecosystem processes and ecological interactions.

Chilling outweighs photoperiod in preventing precocious spring development.

It is well known that increased spring temperatures cause earlier onset dates of leaf unfolding and flowering. However, a temperature increase in winter may be associated with delayed development when species' chilling requirements are not fulfilled. Furthermore, photosensitivity is supposed to interfere with temperature triggers.

Adhesion mechanisms of the contact interface of TiO2 nanoparticles in films and aggregates.

Fundamental knowledge about the mechanisms of adhesion between oxide particles with diameters of few nanometers is impeded by the difficulties associated with direct measurements of contact forces at such a small size scale. Here we develop a strategy based on AFM force spectroscopy combined with all-atom molecular dynamics simulations to quantify and explain the nature of the contact forces between 10 nm small TiO(2) nanoparticles. The method is based on the statistical analysis of the force peaks measured in repeated approaching/retracting loops of an AFM cantilever into a film of nanoparticle agglomerates and relies on the in-situ imaging of the film stretching behavior in an AFM/TEM setup.

Preclinical evaluation of biomarkers for response monitoring to the MET inhibitor BAY-853474.

Context: The receptor tyrosine kinase MET contributes to a wide range of biological activities, including survival, proliferation, and metastasis, which play an important role in cancer progression. MET is frequently overexpressed or amplified in a range of malignancies. Therefore, MET is an attractive therapeutic target for treatment of cancer.

Chlorine isotope fractionation in the stratosphere.

Chlorinated organic compounds are important contributors to the anthropogenic enhancement of stratospheric ozone depletion. We report measurements of stratospheric isotope fractionation in such a compound. Stratospheric and tropospheric difluorodichloromethane (CF2Cl2) were found to have the largest relative 37Cl/35Cl isotope ratio difference ever measured for a natural compound.

Nourishing the body through use of process prescriptions in group therapy.

Objective: This clinical report describes a creative process for developing between-session prescriptions which sustain and strengthen the momentum of change occurring in group treatment sessions.

Method: Therapists in this model use words and phrases depicting the group as a body in order to guide the treatment process and develop between-session prescriptions. Maintaining a perspective of the treatment group as a body facilitates development of member commitment to the well-being of a physical and psychological body, and between-session assignments employ the developmental phases of the therapy for illuminating the disorder and effecting its resolution.

Organometallic Selenolates. 5.(1) Synthesis and Complexing Properties of 2-Propene- and 2-Methyl-2-propeneselenolato Molybdenum and Tungsten Compounds. Crystal Structures of cp(CO)(3)WSeCH(2)C(CH(3))=CH(2), [cp(CO)(2)MoSeCH(2)C(CH(3))=CH(2)](2), [cp(CO)(3)Mo(&mgr;-SeCH(2)C(CH(3))=CH(2))W(CO)(5)], [cp(CO)(3)Mo(&mgr;-SeCH(2)C(CH(3))=CH(2))Mo(CO)(5)], and [cp(CO)(3)Mo(&mgr;-SeCH(2)CH=CH(2))Mo(CO)(5)].

2-Propene- and 2-methyl-2-propeneselenolato complexes of molybdenum(II) and tungsten(II) have been prepared via insertion of gray selenium into alkali-metal-molybdenum and -tungsten bonds and subsequent reaction with allyl and beta-methallyl chlorides. The complexes are monomeric in the solid state. The (beta-methallyl)molybdenum compound cp(CO)(3)MoSeCH(2)C(CH(3))=CH(2) (2) decomposes slowly in solution with CO loss and formation of the corresponding dimer [cp(CO)(2)MoSeCH(2)C(CH(3))=CH(2)](2) (3), whose crystal structure has been determined (C(22)H(24)Mo(2)O(4)Se(2), monoclinic, P2(1)/c, a = 11.

Why group therapy for bulimia?

Many treatment approaches for bulimia rely on the use of a group format. However, descriptions of the treatments do not reveal that the powers of group process are curative in themselves. The dynamics of the group parallel and are metaphorical for the dynamics of the disorder.