Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption.

The Golgi apparatus is a critical organelle responsible for intracellular trafficking and signaling, orchestrating essential processes such as protein and lipid sorting . Dysregulation of its function has been implicated in various pathologies, including obesity, diabetes, and cancer, highlighting its importance as a potential therapeutic target. Despite this, the development of tools to selectively target the Golgi in specific cell types remain a significant unmet challenge in imaging and drug discovery.

Integrin-activating protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets.

Matrigel/BME, a basement membrane-like preparation, supports long-term growth of epithelial 3D organoids from adult stem cells [T. Sato , , 262-265 (2009); T. Sato , , 1762-1772 (2011)].

Evaluating the readability of FDA-approved JAK inhibitor medication guides in dermatology.

Prior studies have highlighted significant challenges in the readability of patient educational materials in dermatology, which may represent a barrier to optimal treatment outcomes. As newer Janus kinase inhibitors (JAKi) gain FDA approval and are integrated into treatment regimens, it is crucial for patients to understand their usage, risks, and benefits. We evaluated the readability of FDA-approved JAKi medication guides to see if lessons from prior readability studies have been incorporated into these newer materials.

Characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies in adults in the UK General Practice: a population-based cohort study.

Objective: To assess the characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies labels in general practice in the UK.

Design: Population-based cohort study.

Setting: Primary care in the UK, 2000-2018.

Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis.

Background: Diabetes increases ischemic heart injury via incompletely understood mechanisms. We recently reported that diabetic adipocytes-derived small extracellular vesicles (sEV) exacerbate myocardial reperfusion (MI/R) injury by promoting cardiomyocyte apoptosis. Combining in vitro mechanistic investigation and in vivo proof-concept demonstration, we determined the underlying molecular mechanism responsible for diabetic sEV-induced cardiomyocyte apoptosis after MI/R.

Cross-facility absolute charge calibration of scintillating screens for laser wakefield accelerated beam diagnostics.

Scintillation screens are widely used to diagnose high-charge density, low-average current electron beams from laser wakefield accelerators (LWFAs). However, the absolute response between emitted photons and electron charge has only been calibrated at a limited number of facilities, and there have been discrepancies between these calibrations. In this report, we comprehensively revised the absolute charge calibration of two high relative brightness scintillating screens of LANEX Regular (Carestream) and PI200 (Mitsubishi) by employing the high-brightness photoinjector at the National Synchrotron Radiation Research Center (NSRRC), which provides electron beams with variable charges (50-350 pC per pulse) and energies (26.

Phytol and bilimbi phytocompounds induce thermogenic adipocyte differentiation: An in vitro study on potential anti-obesity effects.

Obesity is a major health concern associated to diabetes, cardiovascular disease, and cancer. Brown adipocytes, which specialise in thermogenesis, offer a potential therapeutic target for obesity prevention and related conditions. This study builds on previous findings of the browning activity of Averrhoa bilimbi hexane fractions and aims to elucidate the underlying mechanisms in vitro.

Developing an extended process model of emotion regulation in PTSD.

Emotion regulation is a topic of growing interest in the field of post-traumatic stress disorder (PTSD). Despite the field's concentrated efforts in this area, the research has not matched advancements in the general emotion regulation literature, which have proposed more holistic models to understanding to how individuals identify and respond to emotions. In looking at emotion regulation in PTSD, this paper reviews the current state of the literature using the Extended Process Model proposed by Gross (2015).

Effect of stretching ratio on the structure and enactment of porous PVDF-HFP hollow fiber membranes for CO absorption.

Carbon dioxide (CO) is responsible for increment of the Earth surface temperature and the subsequent environmental issues. In this regard, membrane contactor is one of the emerging technologies that can be applied for controlling CO emission. More specifically, the intrinsic structure of membrane plays an important role to govern the performance of CO absorption.

Curriculum innovation: Interactive educational workshop improves neurology resident knowledge of multiple sclerosis.

Introduction: Establishing a solid resident knowledge of multiple sclerosis (MS) during neurology residency is crucial for independent clinical practice. We created a case-based and interactive educational workshop on MS with the aim of improving neurology resident clinical and theoretical knowledge of various aspects of MS diagnosis and care.

Methods: MS neurologists from the University of North Carolina (UNC) School of Medicine designed a 4-hour in-person case-based interactive educational workshop for all neurology residents.

Cultural group and self-construal moderate the association between expressive suppression and posttraumatic stress disorder symptoms.

Few studies have considered the influence of cultural factors on the associations between posttraumatic stress disorder (PTSD) and key emotion regulation strategies, such as expressive suppression and reappraisal. This study investigated the influences of cultural background and self-construal orientation on PTSD symptoms and both suppression and reappraisal. Chinese Australian (n = 129) and European Australian (n = 140) trauma survivors completed an online survey assessing suppression and reappraisal (Emotion Regulation Questionnaire), cultural values (Self Construal Scale), and PTSD symptoms (PTSD Checklist for DSM-5).

Enhancing the accuracy of blood-glucose tests by upgrading FTIR with multiple-reflections, quantum cascade laser, two-dimensional correlation spectroscopy and machine learning.

The accuracy of screening diabetes from non-diabetes is drastically enhanced by strategically upgrading the bench-marking infrared spectroscopy technique for non-invasive tests of blood-glucose, both with state-of-the-art instrumentation-retrofits and with intelligent spectral-datamining tools. First, the signal-to-noise performance of FTIR in measuring the spectral features of a glucose solution containing bovine serum albumin is improved by 2-3 times with the common single-pass attenuated total-reflection setup replaced by a multi-passes-reflections setup. Second, replacing the ordinary infrared lamp with a quantum cascade laser further improves the signal-to-noise by 3 times.

Long- and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection: a multicenter propensity score-matched comparative study.

Background: Gallbladder cancer (GBC) was once considered a contraindication for laparoscopic surgery, but it is becoming more common to use laparoscopic surgery for GBC treatment. The aim of this study was to analyze the long- and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network (NCCN) after laparoscopic resection (LR) versus open resection (OR).

Methods: A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and 2020.

Music therapy improves engagement and initiation for autistic children with mild intellectual disabilities: A randomized controlled study.

This study aimed to evaluate the effectiveness of music therapy (MT) for children with co-occurring autism spectrum disorder (ASD) and intellectual disabilities (ID) and explore whether pre-intervention quantitative electroencephalogram (qEEG) responses can predict outcomes. A randomized controlled trial was conducted with 33 children receiving MT and 34 receiving an active control therapy. Participants received either MT or a non-musical social skills intervention for 45 min weekly over 12 weeks.

A Territory-Wide Follow-Up of Primary and Secondary Extramammary Paget Disease of 2 Decades: Effects of Local Disease on Survival.

Introduction: Extramammary Paget disease (EMPD) is an uncommon malignant cutaneous neoplasm that are divided into primary and secondary forms. In this multicenter study, histologically proven cases of primary and secondary EMPD were reviewed for clinical outcomes with subgroup analysis for secondary EMPD.

Methodology: Cases of EMPD were identified from pathology report of the involved institutions over a period of over 2 decades.

Insight into selenium vacancies enhanced CoSe/MoSe heterojunction nanosheets for hydrazine-assisted electrocatalytic water splitting.

The integration of interface engineering and vacancy engineering was a feasible way to develop highly efficient electrocatalysts toward water electrolysis. Herein, we designed CoSe/MoSe heterojunction nanosheets with abundant Se vacancies (V-CoSe/MoSe) for electrocatalytic water splitting. In the V-CoSe/MoSe electrocatalyst, the electrons more easily transferred from CoSe to MoSe, and interface engineering not only modulated the electronic structure, but also supplied more heterointerfaces and catalytic sites.

Improving cognitive function in Chinese children with ADHD and/or RD through computerized working memory training.

Background: Prior research has found that children with attention-deficit hyperactivity disorder (ADHD) and reading difficulties (RD) are at an elevated risk of developing further cognitive deficits and developmental challenges [1]. ADHD and RD are characterized by a deficit in working memory, which negatively affects learning and behavior. The main aims of this study were to design a working memory training app and examine its effectiveness through a 5-week training program in Chinese children with ADHD and/or RD.

Nomogram for prediction of severe postoperative complications in elective hepato-pancreato-biliary surgery after COVID-19 breakthrough infection: A large multicenter study.

Background: Currently, there is a deficiency in a strong risk prediction framework for precisely evaluating the likelihood of severe postoperative complications in patients undergoing elective hepato-pancreato-biliary surgery subsequent to experiencing breakthrough infection of coronavirus disease 2019 (COVID-19). This study aimed to find factors predicting postoperative complications and construct an innovative nomogram to pinpoint patients who were susceptible to developing severe complications following breakthrough infection of COVID-19 after undergoing elective hepato-pancreato-biliary surgery.

Methods: This multicenter retrospective cohort study included consecutive patients who underwent elective hepato-pancreato-biliary surgeries between January 3 and April 1, 2023 from four hospitals in China.

"It's not a one-person show" E-learning course in neuropalliative care: A qualitative analysis of participants' educational gains and self-reported outcomes.

Objectives: Patients with progressive neurologic illness still lack access to quality palliative care services. Barriers to the comprehensive provision of neuropalliative care include gaps in palliative care education. To address this barrier, a novel international model of neuropalliative care education e-learning program was launched in 2022.