Publications by authors named "Latsaniphone Boutthasavong"
Background: Surveillance of SARS-CoV-2 circulation is mainly based on real-time reverse transcription-polymerase chain reaction, which requires laboratory facilities and cold chain for sample transportation. This is difficult to achieve in remote rural areas of resource-limited settings. The use of dried blood spots shipped at room temperature has shown good efficiency for the detection of arboviral RNA.
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- Fever is a common symptom in patients in South and Southeast Asia, leading to the need for effective diagnostic methods, particularly for malaria, which often results in unnecessary antibiotic use for malaria-negative cases.
- The study evaluates a multiplex rapid diagnostic test (DPP Fever Panel II Assay) designed to identify multiple tropical fever agents in one test, aiming to improve cost-effectiveness and diagnostic accuracy compared to conventional methods.
- Testing involved 300 patients in Laos, comparing whole blood and serum samples using two different DPP readers; results showed no significant difference in diagnostic performance between the two sample types, with whole blood generally yielding better results.
Article Synopsis
- Burkholderia pseudomallei causes melioidosis, a potentially fatal disease prevalent in Southeast Asia and northern Australia, with a high fatality rate when untreated.
- Current diagnosis relies on bacterial culture, which is slow and has low sensitivity, highlighting the need for faster diagnostic methods.
- The Active Melioidosis Detect (AMD) lateral flow immunoassay shows promise by effectively detecting capsular polysaccharide (CPS) from urine samples, which had higher CPS concentrations compared to serum samples, suggesting urine is a better choice for rapid testing.
causes significant global morbidity and mortality, with the highest disease burden in parts of Asia where culture-based diagnosis is often not available. We prospectively evaluated the Active Melioidosis Detect (AMD; InBios International, USA) lateral flow immunoassay (LFI) for rapid detection of in turbid blood cultures, pus, sputum, sterile fluid, urine, and sera. The performance of this test was compared to that of detection using monoclonal antibody latex agglutination (LA) and immunofluorescence assays (IFA), with culture as the gold standard.
View Article and Find Full Text PDFLeptospirosis is a globally important cause of acute febrile illness, and a common cause of non-malarial fever in Asia, Africa, and Latin America. Simple rapid diagnostic tests (RDTs) are needed to enable health-care workers, particularly in low resource settings, to diagnose leptospirosis early and give timely targeted treatment. This study compared four commercially available RDTs to detect human IgM against spp.
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