Cytogenetic, Serum Liver Enzymes and Liver Cell Pathology of the Hampala Barb Fish ) Affected by Toxic Elements in the Contaminated Nam Kok River Near the Sepon Gold-Copper Mine, Lao PDR.

This study aimed to determine toxic element concentrations in aquatic environments, including water and sediment, and in the fish, and to evaluate chromosome abnormalities, serum liver enzyme changes and liver histopathological alterations in from the Nam Kok River near the Sepon gold-copper mine, Lao People's Democratic Republic, as compared with a control area without mining activity. The results revealed significant differences ( < 0.05) in As, Ba, Cu, Fe, Mn, Ni, Se and Zn in water, in all of the studied potentially toxic elements in sediment, and in As, Ba, Cd, Cr, Cu, Mn, Ni, Se, and Zn in the fish between the study and control areas.

Effects of Contamination by Heavy Metals and Metalloids on Chromosomes, Serum Biochemistry and Histopathology of the Bonylip Barb Fish Near Sepon Gold-Copper Mine, Lao PDR.

The objectives of the present study were to determine the concentrations of heavy metals and metalloids in water, sediment and fish, and to assess chromosome aberrations, serum biochemical changes and histopathological alterations in from the Nam Kok river near the Sepon gold-copper mine, Lao People's Democratic Republic compared with the reference area. The results showed that Fe, Mn and Ni in water, As and Cd in sediment as well as As, Cd, Cr, Mn and Ni in muscle samples near the gold-copper mine exceeded standard values. Furthermore, the chromosome assessment in revealed seven types of chromosome aberrations, and the highest total number of chromosome aberrations was a centromere gap.