Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses.

Objective: To determine the pharmacokinetics of voriconazole following IV and PO administration and assess the distribution of voriconazole into body fluids following repeated PO administration in horses.

Animals: 6 clinically normal adult horses.

Procedures: All horses received voriconazole (10 mg/kg) IV and PO (2-week interval between treatments).

Evaluation of a balloon constant rate infusion system for treatment of septic arthritis, septic tenosynovitis, and contaminated synovial wounds: 23 cases (2002-2005).

OBJECTIVE-To determine clinical findings and outcome in horses treated by means of a balloon constant rate infusion system. DESIGN-Retrospective case series. ANIMALS-23 horses.

Cardiopulmonary, blood and peritoneal fluid alterations associated with abdominal insufflation of carbon dioxide in standing horses.

Reasons For Performing Study: Abdominal insufflation is performed routinely during laparoscopy in horses to improve visualisation and facilitate instrument and visceral manipulations during surgery. It has been shown that high-pressure pneumoperitoneum with carbon dioxide (CO2) has deleterious cardiopulmonary effects in dorsally recumbent, mechanically ventilated, halothane-anaesthetised horses. There is no information on the effects of CO2 pneumoperitoneum on cardiopulmonary function and haematology, plasma chemistry and peritoneal fluid (PF) variables in standing sedated horses during laparoscopic surgery.

Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses.

Objective: To determine the pharmacokinetics of fluconazole in horses.

Animals: 6 clinically normal adult horses.

Procedure: Fluconazole (10 mg/kg of body weight) was administered intravenously or orally with 2 weeks between treatments.

Tissue strength and wound morphology of the equine linea alba after ventral median celiotomy.

Objective: To evaluate the tensile strength and wound morphology of the equine linea alba at intervals over 6 months after ventral median celiotomy.

Study Design: Linea alba tensile strength and wound morphology were determined at 2, 4, 8, 16, and 24 weeks postoperatively. Linea alba samples from 3 unoperated horses were used as controls.

Closed one-stage functional end-to-end jejunojejunostomy in horses with use of linear stapling equipment.

Objective: To use gastrointestinal linear stapling instrumentation to perform a closed one-stage functional end-to-end jejunojejunostomy in adult horses as an alternative to a stapled side-to-side jejunojejunostomy.

Study Design: Clinical outcome, anatomic and histological architecture, and anastomotic dimensions were determined at 2, 4, 8, 16, and 24 weeks postoperatively.

Animals Or Sample Population: 18 adult horses.

Epididymal swelling attributable to generalized lymphosarcoma in a stallion.

Aspermia was diagnosed in a 12-year-old Thoroughbred stallion with generalized lymphosarcoma. Invasion of the epididymus by neoplastic cells caused thickening and enlargement of both epididymes. The testes were not affected.

Cytogenetic studies of human brain tumors and their clinical significance. II. Meningioma.

Cytogenetic study of 45 meningiomas from 31 female and 14 male patients are reported. No chromosomal abnormalities were found in nine (20%). These were predominantly meningotheliomatous, and were from younger patients (average age, 46 years).

Cytogenetic studies of human brain tumors and their clinical significance. 1. Medulloblastoma.

Four medulloblastomas were studied cytogenetically with clinical follow-up of the patients. Three of these lesions were diploid and the patients manifested no recurrence at 40, 37 and 36 months respectively. The remaining tumor was aneuploid with 52 chromosomes and the patient expired of the medulloblastoma in 7 months.

Pregnancy and the herniated lumbar disc.

During the last decade, five pregnant patients with symptoms and signs of a herniated lumbar disc were identified among a series of 48,760 consecutive deliveries at William Beaumont Hospital, an incidence of 1:10,000. In all cases, clinical evaluation and electromyography complemented conservative treatment during the final stage of pregnancy. Each patient was delivered by cesarean section.

Scrotal measurements in beef bulls: heritability estimates, breed and test station effects.

Heritability estimates for scrotal circumference and testicular tone at weaning (225 d) and yearling (365 d) were determined from records on 565 bulls from a purebred Angus herd; year, station and breed effects were determined from scrotal circumference records on 2,420 bulls at five tests stations. Year, breed and breed X year effects on scrotal circumference, length, width and volume were determined from records on 347 bulls at one station. Heritability estimates (+/- SE) were .

Brain abscess as a complication of halo traction.

The occurrence of a brain abscess as a complication of halo traction and immobilization in the management of scoliosis is reported. Previous reports suggest that this complication is rare. Unique in this case is the development of an intracerebral abscess without skull perforation by the halo device and without evidence of contiguous spread of infection.