Publications by authors named "Latge A"

Article Synopsis
  • A study evaluated the effectiveness of a diagnostic strategy combining [F]Fluorocholine PET/CT with 4D-CT for patients with primary hyperparathyroidism (pHPT) undergoing surgery.
  • The results showed that PET/CT was significantly more accurate than 4D-CT, with high sensitivity and specificity rates (83% and 97%, respectively), whereas 4D-CT had lower rates (53% sensitivity).
  • When PET/CT results were inconclusive, using the two imaging methods together improved diagnostic accuracy, making it a recommended personalized imaging approach for pHPT patients.
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Fractal lattices, with their self-similar and intricate structures, offer potential platforms for engineering physical properties on the nanoscale and also for realizing and manipulating high order topological insulator states in novel ways. Here we present a theoretical study on localized corner and edge states, emerging from topological phases in Sierpinski Carpet within a $\pi$-flux regime. A topological phase diagram is presented correlating the quadrupole moment with different hopping parameters.

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A 57-year-old woman with history of chronic lymphocytic leukemia was referred to our center for adjuvant 131 I therapy following complete thyroidectomy for differentiated thyroid cancer. Posttherapeutic scintigraphy revealed atypical diffuse osteomedullar uptake. A major drop in lymphocyte count was observed, from 117.

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Purpose: The aims of the study were to evaluate the performance and robustness of [F]fluorocholine PET/CT in detecting hyperfunctioning parathyroid glands in MEN1-related primary hyperparathyroidism (pHPT) at different stages of their disease.

Methods: Retrospective French multicenter study including patients with MEN1 pHPT who underwent [F]fluorocholine PET/CT at initial diagnosis or for evaluation of persistent/recurrent disease. PET/CT were independently reviewed by two readers in a blinded manner.

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A 47-year-old woman with history of hepatocellular carcinoma was referred for F-fluorocholine PET/CT evaluation due to elevated alpha-fetoprotein. The examination showed several peritoneal uptakes and two nodular pelvic foci. Coelioscopic exploration allowed confirmation and resection of multiple peritoneal metastases from hepatocellular carcinoma while pelvic biopsies revealed endometriosis and endosalpingiosis.

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The growing skill in the synthesis processes of new materials has intensified the interest in exploring the properties of systems modeled by more complex lattices. Two-dimensional super-honeycomb lattices, have been investigated in metallic organic frameworks. They turned out as a significant route to the emergence of localized electronic responses manifested as flat bands in their structure with topological isolating behavior.

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Introduction: To investigate the value of presurgical F-FCH PET/CT in detecting additional hyperfunctioning parathyroids despite a positive Tc-sestamibi parathyroid scintigraphy in patients with primary hyperparathyroidism (pHPT).

Methods: This is a retrospective study involving patients with pHPT, positive parathyroid scintigraphy performed before F-FCH PET/CT, and parathyroid surgery achieved after PET/CT. Imaging procedures were performed according to the EANM practice guidelines.

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All-carbon systems have proven to present interesting transport properties and are often used in electronic devices. Motivated by recent resonant responses measured on graphene/fullerene junction, we propose coupled nanoribbons/carbon-nanotube heterostructures for use as charge filters and to allow tuned transport. These hybrid systems are engineered as a four-terminal device, and we explore multiple combinations of source and collector leads.

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CuCl is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of CuCl in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. F-FDG was used as a comparator.

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The Sierpinski triangle (ST) is a fractal mathematical structure that has been used to explore the emergence of flat bands in lattices of different geometries and dimensions in condensed matter. Here we look into fractal features in the electronic properties of ST flakes and molecular chains simulating experimental synthesized fractal nanostructures. We use a single-orbital tight binding model to study the fractal properties of the electronic states and the Landauer formalism to explore transport responses of the quasi 1D molecular chains.

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Carbon materials are vital for sustainable energy applications based on abundant and non-toxic raw materials. In this scenario, carbon nanoribbons have superior thermoelectric properties in comparison with their 2D material counterparts, owing to their particular electronic and transport properties. Therefore, we explore the electronic and thermoelectric properties of bilayer α-graphyne nanoribbons (α-BGyNRs) by means of density functional theory, tight-binding, and the non-equilibrium Green's functions (NEGF) method.

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Patients with primary hyperparathyroidism (pHPT) can develop persistent (P-pHPT) or recurrent (R-pHPT) disease after parathyroidectomy. Before recommending reoperation, recurrence must be accurately identified because of the high risk of complications. Our study evaluates F-fluorocholine (F-FCH) PET/CT and 4D-CT integrated in PET/4D-CT in patients with P-pHPT/R-pHPT.

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Purpose: Thyroid nodules frequently coexist with primary hyperparathyroidism (pHPT). Because of the increasing use of 18F-fluorocholine (18F-FCH) PET/CT in patients with pHPT, evaluation of its clinical utility for thyroid nodules characterization in this population is of paramount importance. Herein, we investigate the value of dual-point 18F-FCH PET/CT in the diagnosis of thyroid cancer in patients referred for pHPT imaging who have thyroid nodules.

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Introduction: Despite the increasing use of F-fluorocholine ( F-FCH) positron emission tomography (PET) in patients with prostate cancer, the acquisition protocol remains debated. We have evaluated the influence of the pelvic dynamic phase on the final reading of whole-body F-FCH PET, to assess the need for a two-stage protocol. Reading the physician's experience and patient's previous treatment profile was also considered as potential influencing factors on final PET interpretation.

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We analyze the electronic properties of a hybrid graphene-BN nanoribbon system, using a Hubbard model Hamiltonian within a mean field approximation. Due to the different electronegativities of the boron and nitrogen atoms, an electric field is induced across the zigzag graphene strip, breaking the spin degeneracy of the electronic band structure. Optimal tight-binding parameters are found from first-principles calculations.

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Thermoelectric properties of hybrid systems composed of graphene nanoribbons (GNRs) coupled to rectangular rings or functionalized with aromatic carbon molecules are theoretically addressed here. Graphene-based nanostructures are designed with the purpose of enhancing thermopower responses compared to the thermal performance of pristine GNRs. The electronic transport is calculated using standard tight binding models and the Landauer transport formalism.

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We report the results of serial F-FDG PET/CT investigations in a 49-year-old woman presenting with an advanced cecal high-grade neuroendocrine carcinoma harboring a somatic BRAF mutation. Patient was refractory to standard chemotherapy regimen showing life-threatening hyperlactatemia. Early after the beginning of BRAF-MEK therapy (dabrafenib and trametinib), impressive improvement in PET/CT imaging was achieved.

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Here we present a theoretical study of the optical properties of graphene nanocones tuned by external electric and magnetic fields. We investigate the effects of the size and topology of the carbon nanostructures on the density of states and on the electro- and magneto-absorption of linearly polarized electromagnetic radiation in different nanocone geometries. We find that the electric field induces changes in the electric charge distribution mainly at the cone edges.

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Among the different strategies used to induce the opening of a band gap in graphene, one common practice is through chemical doping. While a gap may be opened in this way, disorder-induced scattering is an unwanted side-effect that impacts the electron mobility in the conductive regime of the system. However, this undesirable side effect is known to be minimised if dopants interact asymmetrically with the two sublattices of graphene.

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The lack of some spatial symmetries in planar devices with Rashba spin-orbit interactions opens up the possibility of producing spin polarized electrical currents in the absence of external magnetic fields or magnetic impurities. We study how the direction of the spin polarization of the current is related to spatial symmetries of the device. As an example of these relations we study numerically the spin-resolved current in graphene nanoribbons.

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We study transport properties of hexagonal zigzag graphene quantum rings connected to semi-infinite nanoribbons. Open two-fold symmetric structures support localized states that can be traced back to those existing in the isolated six-fold symmetric rings. Using a tight-binding Hamiltonian within the Green's function formalism, we show that an external magnetic field promotes these localized states to Fano resonances with robust signatures in transport.

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Spin excitations in zigzag graphene nanoribbons are studied when the system is subjected to an electric field in the transversal direction. The magnetic properties and the lifetime of the spin excitations are systematically investigated and compared using a tight-binding electron-electron model treated by a mean-field Hubbard model. The effects of electron-hole asymmetry introduced by next-nearest neighbor hopping are also investigated.

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: A theoretical study of electronic and optical properties of graphene nanodisks and nanocones is presented within the framework of a tight-binding scheme. The electronic densities of states and absorption coefficients are calculated for such structures with different sizes and topologies. A discrete position approximation is used to describe the electronic states taking into account the effect of the overlap integral to first order.

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We report on theoretical studies of electronic transport in the archetypical molecular hybrid formed by DNA wrapped around single-walled carbon nanotubes (CNTs). Using a Green's function formalism in a π-orbital tight-binding representation, we investigate the role that spin-orbit interactions play on the CNT in the case of the helicoidal electric field induced by the polar nature of the adsorbed DNA molecule. We find that spin polarization of the current can take place in the absence of magnetic fields, depending strongly on the direction of the wrapping and length of the helicoidal field.

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