What do synergies do? Effects of secondary constraints on multidigit synergies in accurate force-production tasks.

We used the framework of the uncontrolled manifold (UCM) hypothesis to explore changes in the structure of variability in multifinger force-production tasks when a secondary task was introduced. Healthy young subjects produced several levels of the total force by pressing with the four fingers of the hand on force sensors. The frame with the sensors rested on the table (Stable condition) or on a narrow supporting beam (Unstable conditions) that could be placed between different finger pairs.

Learning motor synergies by persons with Down syndrome.

Persons with Down syndrome are frequently described as 'clumsy'. The recent progress in the development of quantitative approaches to motor synergies has allowed researchers to move towards an understanding of 'clumsiness' at the level of underlying control mechanisms. This progress has also offered an opportunity to quantify changes in motor synergies that accompany improvement in the performance of motor tasks.

A device for testing the intrinsic muscles of the hand.

Testing intrinsic function in the past has been primarily via coordination tests such as the Minnesota Rate of Manipulation Tests, Purdue Pegboard Test, Valpar Work Sample, The Crawford, to name a few. Typically as therapists we will use exercise putty and various techniques in the clinic to strengthen these important functional muscles of the hand. However, measuring the strength of these muscles has been very limited and time-consuming.

Similar motion of a hand-held object may trigger nonsimilar grip force adjustments.

The tight coupling between load (L) and grip (G) forces during voluntary manipulation of a hand-held object is well established. The current study is to examine grip-load force coupling when motion of the hand with an object was either self-generated (voluntary) or externally generated. Subjects performed similar cyclic movements of different loads at various frequencies with three types of manipulations: 1) voluntary oscillation, 2) oscillating the right arm via the pulley system by the left leg (self-driven oscillation), and 3) oscillating the arm via the pulley system by another person (other-driven oscillation).

Learning effects on muscle modes and multi-mode postural synergies.

We used the framework of the uncontrolled manifold hypothesis to explore the effects of practice on the composition of muscle groups (M-modes) and multi-M-mode synergies stabilizing the location of the center of pressure (COP). In particular, we tested a hypothesis that practice could lead to a transition from co-contraction muscle activation patterns to reciprocal patterns. We also tested a hypothesis that new sets of M-modes would form stronger synergies stabilizing COP location.

Toward a new theory of motor synergies.

Driven by recent empirical studies, we offer a new understanding of the degrees of freedom problem, and propose a refined concept of synergy as a neural organization that ensures a one-to-many mapping of variables providing for both stability of important performance variables and flexibility of motor patterns to deal with possible perturbations and/or secondary tasks. Empirical evidence is reviewed, including a discussion of the operationalization of stability/flexibility through the method of the uncontrolled manifold. We show how this concept establishes links between the various accounts for how movement is organized in redundant effector systems.

Emerging and disappearing synergies in a hierarchically controlled system.

The purpose of the study was to explore the ability of the central nervous system (CNS) to organize synergies at two levels of a hypothetical control hierarchy involved in two-hand, multi-finger tasks. We investigated indices (DeltaV) of finger force co-variation across trials as reflections of synergies stabilizing the total force (F (TOT)). Subjects produced constant force with one or two finger-pairs (from one hand or two hands).

Adjustments to local friction in multifinger prehension.

The authors studied the effects of surface friction at the digit-object interface on digit forces and moments when 12 participants statically held an object in a 5-digit grasp. The authors changed low-friction contact (LFC) with rayon and high-friction contact (HFC) with sandpaper independently for each digit in all 32 possible combinations. Normal forces of the thumb and virtual finger (VF), an imagined finger with a mechanical effect equal to that of the 4 fingers, increased with the thumb at LFC or with an increase in the number of fingers at LFC.

Anticipatory control of head posture.

Objective: We tested a hypothesis on two patterns of anticipatory postural adjustments (APAs) in neck muscles, reciprocal and co-activation, that may be used in a task-specific way. We also explored possible relation of APAs in leg and trunk muscles to head stabilization.

Methods: Load perturbations (loading and unloading) were applied to the head, trunk, and head and trunk simultaneously using similar hand actions by standing persons.

Prehension synergies in the grasps with complex friction patterns: local versus synergic effects and the template control.

We studied adjustments of digit forces to changes in the friction. The subjects held a handle statically in a three-digit grasp. The friction under each digit was either high or low, resulting in eight three-element friction sets (such grasps were coined the grasps with complex friction pattern).

Finger interaction during maximal radial and ulnar deviation efforts: experimental data and linear neural network modeling.

The purpose of this study was to characterize finger interactions during radial/ulnar deviation, including interactions with flexion movements. Subjects performed single-finger and multi-finger maximal voluntary contraction (MVC), and maximal forces and various indices of interaction among the fingers were quantified. MVCs in radial/ulnar deviation were 50-80% as strong as in flexion.

Effects of postural task requirements on the speed-accuracy trade-off.

We investigated the speed-accuracy trade-off in a task of pointing with the big toe of the right foot by a standing person that was designed to accentuate the importance of postural adjustments. This was done to test two hypotheses: (1) movement time during foot pointing will scale linearly with ID during target width changes, but the scaling will differ across movement distances; and (2) variations in movement time will be reflected in postural preparations to foot motion. Ten healthy adults stood on the force plate and were instructed to point with the big toe of the right foot at a target (with widths varying from 2 to 10 cm) placed on the floor in front of the subject at a distance varying from 10 to 100 cm.

Muscle modes and synergies during voluntary body sway.

We studied the coordination of muscle activity during voluntary body sway performed by human subjects at different frequencies. Subjects stood on the force platform and performed cyclic shifts of the center of pressure (COP) while being paced by the metronome. A major question was: does the makeup of muscle synergies and their ability to assure reproducible sway trajectory vary with the speed of the sway? Principal component analysis was used to identify three muscle groups (M-modes) within the space of integrated indices of muscle activity.

Age-related changes in multifinger synergies in accurate moment of force production tasks.

The purpose of this investigation was to document and quantify age-related differences in the coordination of fingers during a task that required production of an accurate time profile of the total moment of force by the four fingers of a hand. We hypothesized that elderly subjects would show a decreased ability to stabilize a time profile of the total moment of force, leading to larger indexes of moment variability compared with young subjects. The subjects followed a trapezoidal template on a computer screen by producing a time profile of the total moment of force while pressing down on force sensors with the four fingers of the right (dominant) hand.

The use of flexible arm muscle synergies to perform an isometric stabilization task.

Objective: To evaluate if functional synergies are comprised of flexible combinations of a small number of ensembles of upper limb muscles to stabilize a particular performance variable during a force production task.

Methods: Electromyographic (EMG) signals of wrist, elbow and shoulder muscles were recorded. Linear combinations of indices of the integrated EMG of nine muscles (muscle modes or M-modes) and their relationship to changes in the moment of force produced by the right arm of subjects about the horizontal axis of a handle were first determined.

Hierarchies of synergies: an example of two-hand, multi-finger tasks.

We explored the ability of the central nervous system (CNS) to assemble synergies stabilizing the output of sets of effectors at two levels of a control hierarchy. Specifically, we asked a question: can the CNS organize both two-hand and within-a-hand force stabilizing synergies in a simple two-hand force production task that involves two fingers per hand? Intuitively, one could expect a positive answer; that is, forces produced by each hand are expected to co-vary negatively across trials to bring down the total force variability, while forces produced by each finger within-a-hand are expected to co-vary negatively to reduce the variability of that hand's contribution to the total force. The subjects were instructed to follow a trapezoidal time profile with the signal corresponding to the force produced by a set of instructed fingers in one-hand tasks with two-finger force production and in two-hand tasks with involvement of both symmetrical and asymmetrical finger pairs in the two hands.

Elderly show decreased adjustments of motor synergies in preparation to action.

Background: Aging is associated with decreased manual dexterity. Recent findings have identified changes in multi-finger synergies in elderly individuals. The purpose of current work was to study age-related changes in adjustments of multi-finger synergies in preparation to a quick targeted force pulse production task.

Hand dominance and multi-finger synergies.

Recent studies of arm movement reaching to a target have provided support for the Dynamic Dominance model of handedness, which proposes that each hemisphere/limb system is specialized for controlling different features of performance: The dominant system for control of the trajectory, and the nondominant system for control of the steady state final position. We now examine a more general form of this hypothesis by investigating differences between the right and left hands of right-handed persons in their ability to stabilize the combined action of a set of fingers. The subjects produced very quick pulses and steps of force from a low background force level while pressing with four fingers of one hand.

Finger synergies during multi-finger cyclic production of moment of force.

We investigated multi-finger synergies stabilizing the total moment of force and the total force when the subjects produced a quick cyclic change in the total moment of force. The seated subjects performed the task with the fingers of the dominant arm while paced by the metronome at 1.33 Hz.

Stepping from a narrow support.

The study addresses postural preparation to stepping. In particular, it tests a hypothesis that such preparation involves adjustments in the activity of ankle plantarflexors to produce shifts of the center of pressure. We investigated the initiation of a step from quiet stance when the subjects stood on boards with a decreased dimension of the support area in the anterior-posterior direction ("unstable boards").

Synergies in health and disease: relations to adaptive changes in motor coordination.

This article describes an approach to motor synergies that allows them to be quantified in people with atypical movement patterns during exercise or practice. Within this approach, motor variability may be classified with respect to a task-specific performance variable as "good" (not affecting the variable) or "bad" (changing the variable). The authors review studies of motor synergies in people with typical movement patterns, in people with Down syndrome, in patients after stroke, and in elderly people.

The role of kinematic redundancy in adaptation of reaching.

Although important differences exist between learning a new motor skill and adapting a well-learned skill to new environmental constraints, studies of force field adaptation have been used frequently in recent years to identify processes underlying learning. Most of these studies have been of reaching tasks that were each hand position was specified by a unique combination of joint angles. At the same time, evidence has been provided from a variety of tasks that the central nervous system takes advantage of the redundancy available to it when planning and executing functional movements.

Feed-forward control of a redundant motor system.

We describe a model of feed-forward control of a redundant motor system and validate it using, as examples, tasks of multi-finger force production. The model assumes the existence of two input signals at an upper level of the control hierarchy, related and unrelated to a task variable. Knowledge of the Jacobian of the system is assumed at the level of generation of elemental variables (variables at the level of effectors).

Adjustments of prehension synergies in response to self-triggered and experimenter-triggered load and torque perturbations.

Humans are known to show anticipatory adjustments in the grip force prior to a self-generated or predictable action or perturbation applied to a hand-held object. We investigated whether humans can also adjust covariation of individual finger forces (multi-finger synergies) prior to self-triggered perturbations. To address this issue, we studied adjustments in multi-digit synergies associated with applied load/torque perturbations while the subjects held a customized handle steadily.

Accurate production of time-varying patterns of the moment of force in multi-finger tasks.

We investigated the production of time profiles of the total moment of force produced in isometric conditions by the four fingers of a hand. We hypothesized that these tasks would be associated with multi-finger synergies stabilizing the time profile of the total moment across trials but not necessarily stabilizing the time profile of the total force produced by the fingers. We also expected the multi-finger synergies to prevent an increase in the moment variability with its magnitude.