Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism.

Objective: The insulin tolerance test (ITT) is contraindicated in a proportion of patients with suspected ACTH deficiency. The aim of this study was to investigate the diagnostic accuracy of the glucagon stress test (GST) compared with the overnight metyrapone test (OMT) in patients with contraindications to ITT.

Design: This was a prospective comparison of the GST to the OMT in patients with suspected ACTH deficiency and contraindications to the ITT.

Maternal C-reactive protein levels in patients undergoing frozen embryo replacement cycles: a prospective study.

This prospective study shows that the early pregnancy inflammatory response following frozen embryo replacement (FER) cycles may be absent or suppressed, in contrast to that following IVF. To our knowledge, this is the first study to evaluate the maternal inflammatory response following FER cycles, but larger studies are still required to explore this novel finding, and investigate whether this may explain the lower ongoing pregnancy rates generally achieved following FER cycles.