Targeting the membrane-proximal domain of CD33 to maximize the efficacy of natural killer cell-based immunotherapies.

Not available.

The Lasiocampidae (Lepidoptera: Lasiocampoidea) of Maputo Special Reserve, Mozambique: a provisional checklist with descriptions of three new species and taxonomic notes.

A preliminary checklist of 39 species of lappet moths (Lasiocampidae) is provided for Maputo Special Reserve in southern Mozambique of which three are new to science, Diapalpus smithi sp. n., Eutricha giustii sp.

Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders.

Current treatments for eosinophilic and mast cell disorders are often ineffective. One promising target to improve outcomes is sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8). As limitations, there are few Siglec-8 monoclonal antibodies (mAbs) available to date, and Siglec-8-directed treatments have so far primarily focused on unconjugated mAbs, which may be inadequate, especially against mast cells.

Targeting the membrane-proximal C2-set domain of CD33 for improved CAR T cell therapy.

Current CD33-targeted immunotherapies typically recognize the membrane-distal V-set domain of CD33. Here, we show that decreasing the distance between T cell and leukemia cell membrane increases the efficacy of CD33 chimeric antigen receptor (CAR) T cells. We therefore generated and optimized second-generation CAR constructs containing single-chain variable fragments from antibodies raised against the membrane-proximal C2-set domain, which bind CD33 regardless of whether the V-set domain is present (CD33 antibodies).

Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16a/NKG2D Immune-Modulating TriNKET CC-96191.

Increasing efforts are focusing on natural killer (NK) cell immunotherapies for AML. Here, we characterized CC-96191, a novel CD33/CD16a/NKG2D immune-modulating TriNKET. CC-96191 simultaneously binds CD33, NKG2D, and CD16a, with NKG2D and CD16a co-engagement increasing the avidity for, and activation of, NK cells.

Surprising discovery of an enigmatic geometrid in Croatia: , gen. nov., sp. nov. (Lepidoptera, Geometridae).

A new monotypic genus of Geometridae, , and a new species, , are described from Croatia. Based on external and genitalia characters, the new genus is tentatively placed in the subfamily Larentiinae. However, the new genus takes a highly isolated position by having unique characters of the tympanum and showing an unusually long pectination of female antennae.

Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates.

Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted on-target, off-tumor toxicities. Deletion or modification of such targets to protect normal HSPCs is, therefore, of great interest. Although HSPC modifications commonly aim to mimic naturally occurring phenotypes, the long-term persistence and safety of gene-edited cells need to be evaluated.

Integrative taxonomic revision of the African taxa of the Racotis Moore, 1887 generic complex (Lepidoptera, Geometridae, Ennominae, Boarmiini).

The Afrotropical taxa of the Racotis s.l. generic complex are revised utilising integrative taxonomical methods.

Five new species of the genus Meganaclia Aurivillius, 1892 (Lepidoptera: Erebidae: Arctiinae: Syntomini).

The Afrotropical genus Meganaclia Aurivillius, 1892 is revised, five new species M. smithi sp. n.

Two new Nolini (Lepidoptera: Nolidae: Nolinae) from Nouabalé-Ndoki National Park, Republic of Congo.

A new species of Bellanola László, 2022 (B. ndoki László, sp. n.

Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy.

On-target toxicity to normal cells is a major safety concern with targeted immune and gene therapies. Here, we developed a base editing (BE) approach exploiting a naturally occurring CD33 single nucleotide polymorphism leading to removal of full-length CD33 surface expression on edited cells. CD33 editing in human and nonhuman primate (NHP) hematopoietic stem and progenitor cells (HSPCs) protects from CD33-targeted therapeutics without affecting normal hematopoiesis , thus demonstrating potential for novel immunotherapies with reduced off-leukemia toxicity.

Examination of effects of indoor fires on building structures and people.

The scientific study of the harmful effects of indoor fires on building structures and on the environment is a top issue today. Indoor fires frequently occur all over the world. The goal of our research is to examine the effects of an average room fire on the survival possibility of a trapped person and on the building structure, taking into account features of the Eastern European architecture.

Notes on some Tanzanian butterfly specimens in the Suffert Collection: a case of patria/ falsa/.

A number of mislabelled butterfly specimens in the Suffert collection purporting to be from Lindi in southeast Tanzania belong to taxa restricted to the Usambara Mountains in northeast Tanzania thus suggesting patria falsa. The history of Suffert's collection and the possible reasons behind this mislabelling event are discussed in more detail. One of the mislabelled specimens, the holotype of Papilio illyris hamatus Joicey Talbot, 1918 described from Tanzania, is the senior name for Graphium illyris girardeaui Guilbot Plantrou, 1978, the latter name formally synonymised herein with the former.

Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy.

There is increasing interest in targeting CD33 in malignant and non-malignant disorders. In acute myeloid leukemia, longer survival with the CD33 antibody-drug conjugate gemtuzumab ozogamicin (GO) validates this strategy. Still, GO benefits only some patients, prompting efforts to develop more potent CD33-directed therapeutics.

Review of the Cyana rejecta (Walker, 1854) species-group, with descriptions of three new species from mainland Africa and a new subspecies from Madagascar (Lepidoptera, Erebidae, Arctiinae, Lithosiini).

The present paper provides an overview of the Cyana rejecta (Walker, 1854) species-group. Three new species (C. yao sp.

Review of the genus Meganola Dyar, 1898 of Ivory Coast and adjacent areas with descriptions of 5 new species and several taxonomic updates (Lepidoptera, Nolidae, Nolinae)-Taxonomic studies on West African Nolinae I.

The present paper contains the first comprehensive taxonomic summary of the Meganola Dyar, 1898 species recorded in Ivory Coast and adjacent areas. 35 species are recorded in total with 28 species having been collected on recent African Natural History Research Trust expeditions. All species are listed with label data of specimens examined together with 56 colour and 52 black and white illustrations of the adults and their genitalia.

First record of the genus Porcellanola László, Ronkay amp; Witt, 2006 (Lepidoptera, Nolidae, Nolinae) from India with description of a new species.

Genus Porcellanola is reported for the first time from India with description of a new species, Porcellanola sikkima Joshi, Singh László sp. nov., (Sikkim) along with the morphotaxonomy of two more species, P.

On the taxonomic position of 'Siccia' yvonneae Kühne, 2007 (Lepidoptera: Nolidae: Nolinae).

Siccia yvonneae Kühne, 2007 described as member of Lithosiini (Erebidae, Arctiinae) is transferred in the present paper to the genus Meganola Dyar, 1898 of Nolini (Nolidae, Nolinae): Meganola yvonneae (Kühne, 2007), comb. nov. Meganola yvonneae is compared to M.

On the taxonomy of the subgenera Cyabarda Karisch, 2013, Idiovulpecula Karisch, 2013 and Paravulpeculella Karisch, 2013 of the genus Cyana Walker, 1854, with descriptions of three new species from africa (Lepidoptera, Erebidae, Arctiinae, Lithosiini).

The identification of the male of Cyana (Cyabarda) torrida (Holland, 1893) is corrected, the male is illustrated for the first time. Cyana suessmuthi Karisch, 2013 is transferred to the subgenus Cyabarda Karisch, 2013, its female adult and female genitalia are illustrated and diagnosed for the first time. A new species Cyana (Cyabarda) nambi sp.