[Contents of catecholamines and corticosteroids in tissues of quinea pigs with C-hypovitaminosis].

On the 12-14th day of the scorbutigenic regime simultaneously with a decrease in the level of ascorbic acid in the guinea pig tissues to content of catecholamines and 11-oxycorticosteroids changes as well. The amount of adrenalin in the adrenal tissue drops, that of epinephrine in the brain tissue and liver rises. The content of glucocorticoids in adrenals and blood plasm increases.

[Effect of ascorbic acid on glucocorticoid metabolism in guinea pigs].

Ascorbic acid administered for 18-20 days (daily by 100 mg per 1 kg of weight per os) causes redistribution of certain fractions of 17-OCS excreted with urine (a decrease in the content of free F and F/E ratio, an increase in the content of THF, THE and THS, a more frequent appearance of substances). In the blood plasm and adrenals concentration of 11-OCS rises. When determining the available functional reserves of the adrenal cortex under these conditions, an increase in the content of F, E and S unchanged forms is observed in response to ACTH administration as distinct from the initial state.

[Effect of ethyl ether of p-chlorphenoxyisobutyric acid on the glucocorticoid function of the adrenal cortex of guinea pigs].

In administration to quinea pigs of ethyl-p-chlorophenoxyisobutyrate daily in a dose of 0.2 g/kg per os for 15-26 days decreased the 17-OHCS concentration in the peripheral blood plasma. A fall of the urinary excretion of individual 17-OHCS occurred chiefly at the expense of free unchanged cortisol, tetrahydrocortisol and tetrahydro-11-desoxycortisol.