Hematological ratios in patients with acute decompensation and acute-on-chronic liver failure: prognostic factors.

Background And Aims: Acute-on-chronic liver failure (ACLF) is the most severe form of acutely decompensated cirrhosis and is characterized by the presence of intense systemic inflammation. Leucocyte quantification can serve as an indirect indicator of systemic inflammation. In our study, we investigated the predictive value of hematological ratios (neutrophils to lymphocytes, monocyte to lymphocytes, platelets to lymphocytes, lymphocytes to C-reactive protein, and neutrophils to lymphocytes and platelets) in acute decompensation (AD) and ACLF patients and their relation to disease severity and early mortality.

Fructose improves titanium dioxide nanoparticles induced alterations in developmental competence of mouse oocytes.

Aims: We investigated the effects of intraperitoneal injections of titanium dioxide nanoparticles (TiO NPs, 100 mg/kg) for 5 consecutive days on the developmental competence of murine oocytes. Furthermore, study the effects of TiO NPs on antioxidant and oxidative stress biomarkers, as well as their effects on expression of apoptotic and hypoxia inducing factor-1α (HIF1A) protein translation. Moreover, the possible ameliorating effects of intraperitoneal injections of fructose (2.

Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial.

Objectives: Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatric FC.

Age-related morphological and ultrastructural changes in the palate and pharyngeal masticatory apparatus of grass carp (Ctenopharyngodon idella) juveniles.

Grass carp (Ctenopharyngodon idella or C. idella) is a Cyprinid fish frequently utilized for aquaculture, medical, and research purposes. In C.

Efficacy of Vonoprazan vs. Pantoprazole or Non-acid Suppression in Prevention of Post-variceal Ligation Ulcer Bleeding in Portal Hypertension: A Multi-arm Randomized Controlled Trial.

Background: Up-to-date data about the role of acid suppression therapy e.g. proton-pump inhibitors; to reduce post-endoscopic variceal ligation (EVL) ulcer-bleeding are conflicting.

Vibration Controlled Transient Elastography in Screening for Silent Liver Diseases.

Objectives: The objective of this study was to screen for significant hepatic fibrosis or steatosis in asymptomatic, apparently healthy subjects by using Vibration-controlled transient elastography and controlled attenuation parameter (CAP).

Methods: Prospectively, 433 asymptomatic apparently healthy adults were included. Fibroscan/CAP examination was performed for all of them.

Impact of chitosan administration on titanium dioxide nanoparticles induced testicular dysfunction.

The potential reproductive toxic effects of oral TiO NPs in adult male rats as well as the possible alleviation of chitosan administration was investigated. Animals were allocated to four groups; the first group received deionized water and was assigned as a control group. In the second group, rats received chitosan at a dose of 5 mg/kg BW/day.

β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study.

Background: Portal hypertension, a common complication associated with liver cirrhosis, can result in variceal bleeding, which greatly impacts patient survival. Recently, β-arrestin-2 has been shown to predict the acute hemodynamic response to nonselective β-blocker therapy for cirrhotic portal hypertension. However, more data is needed on the long-term effects of and changes in β-arrestin-2 following nonselective β-blocker therapy.

Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat.

Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, anti-inflammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) after their transplantation into rats, with the ibotenic (IBO) acid-induced cognitive deficit model. After 7 weeks, cognitive functions were assessed using the Morris water maze (MWM).

Chitosan attenuated the neurotoxicity-induced titanium dioxide nanoparticles in brain of adult rats.

In the current study, we aimed to investigate the neurotoxic effect of oral titanium dioxide nanoparticles (TiO NPs) as well as the possible neuroprotective effect of carboxymethyl chitosan in adult rats for 14 days. The results revealed that TiO NPs inhibited the activity of the acetylcholine esterase enzyme and the levels of serotonin, dopamine, and norepinephrine neurotransmitters. Additionally, it induced neuro-oxidative stress and neuroinflammation via an elevation in MDA levels and IL-6, while GSH concentration, as well as GPx and GST activities, were decreased.

Colorectal cancer in Arab world: A systematic review.

Background: The incidence of colorectal cancer (CRC) is increasing among young individuals in the Arab world as well as in other regions of the world.

Aim: To explore the incidence and prevalence of CRC in the Arab world.

Methods: The PubMed, Scopus, Web of Science, EBSCO and Wiley databases were searched to retrieve relevant articles irrespective of the language or the publication year.

Efficacy of Lactoferrin with Standard Triple Therapy or Sequential Therapy for Helicobacter pylori Eradication: A Randomized Controlled Trial.

Background: Bovine lactoferrin addition to regimens of Helicobacter pylori treatment has been tried, with conflicting results.

Aim: To assess the effect of bovine lactoferrin in addition to the anti-H. pylori treatment.

Posthatching ultrastructural development of the oropharyngeal cavity roof in five age-stages of Coturnix coturnix (Linnaeus, 1758).

Recent literature has demonstrated only adult avian palate, albeit there has been only limited focus on the postnatal development of the avian oropharyngeal cavity roof. Hence, the current investigation was designed to obtain the full ultrastructure postnatal description of the oropharyngeal roof during the five developmental age-stages of Coturnix coturnix by employing assessments using gross morphometric analysis and stero and scanning electron microscopy. The elongated triangular oropharyngeal roof has a spoonful rounded beak tip.

Hepatocellular carcinoma recurrence after directly acting antivirals for chronic hepatitis C: a 2-year follow-up study.

Aim Of The Study: Data regarding hepatocellular carcinoma (HCC) recurrence after directly acting antivirals for hepatitis C are contradictory. Our aim was to study the HCC recurrence in patients who received directly acting antivirals after tumor ablation.

Material And Methods: This retrospective study included all Child-Pugh A and B patients with hepatitis C related < 5 cm single or up to 3 HCC without any vascular or extrahepatic involvement whose lesions were managed using microwave or radiofrequency ablation at the Internal Medicine Department of Alexandria Faculty of Medicine, in the period from 1 January 2016 to 31 December 2016, and then received directly acting antivirals.

Posthatching developmental studies on the tongue and laryngeal entrance of the common quail (Coturnix coturnix, Linnaeus, 1758) in different five age-stages.

The present study represents the first trial to characterize the ultrastructural of five ages of Coturnix coturnix. Lingual nail had membrane that differ in number among five studied ages. Filiform papillary system had four caudally directed papillae types; small (apex, rostral, and median part of body in 1 day, body in 10 and 20 days), long (apex and rostral part of body in 10 days, tip and two lateral area in 20, 30, 40-days, lateral border in 1 and 10 days, two lateral area of body in 40 days), broad (median area of body in 20, 30, 40 days).

Barriers for resuming endoscopy service in the context of COVID-19 pandemic: A multicenter survey from Egypt.

Background: The current coronavirus disease 2019 (COVID-19) pandemic has affected routine endoscopy service across the gastroenterology community. This led to the suspension of service provision for elective cases.

Aim: To assess the potential barriers for resuming the endoscopy service in Egypt.

Direct antiviral drugs in the treatment of hepatitis C-infected rheumatoid arthritis Egyptian cohort: safety and clinical impact.

Background And Aim: Data about the safety and efficacy of direct-acting antivirals (DAAs) in the treatment of hepatitis C virus (HCV) patients with concomitant rheumatoid arthritis (RA) are scarce. We assessed the impact and safety of DAAs treatment of hepatitis C on rheumatoid arthritis disease activity.

Patients And Methods: Prospectively, we enrolled 65 patients with RA and HCV.

Synergistic effects of Ficus Carica extract and extra virgin olive oil against oxidative injury, cytokine liberation, and inflammation mediated by 5-Fluorouracil in cardiac and renal tissues of male albino rats.

5-Fluorouracil (5-FU), a chemotherapeutic drug, has adverse effects on heart and kidney functions. Ficus Carica (fig) and extra virgin olive oil (EVOO) are natural sources which have antioxidant effects. This study investigated the synergistic effects of fig extract and EVOO against cardiac and renal damage induced by 5-FU.

Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis.

Background: Risk stratification and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior.

Methods: Totally 121 naïve patients with HCC were included.

Xeno-free trans-differentiation of adipose tissue-derived mesenchymal stem cells into glial and neuronal cells.

Mesenchymal stem cells (MSCs) are undifferentiated cells that have the ability of self-renewal and trans-differentiation into other cell types. They hold out hope for finding a cure for many diseases. Nevertheless, there are still some obstacles that limit their clinical transplantation.