Persistent Sitting and Walking Difficulties After Abdominoperineal Excision and Anterior Resection: Results From the Quality of Life in Rectal Cancer (QoLiRECT) Study.

Background: The main surgical resection options in rectal cancer are anterior resection for tumors in the mid- or upper rectum and abdominoperineal excision for tumors in the lower rectum. A previous study showed long-term persistent perineal symptoms and sitting difficulties after abdominoperineal excision.

Objective: To examine the prevalence and extent of sitting and walking difficulties after abdominoperineal excision compared with anterior resection.

Deep learning-based Intraoperative MRI reconstruction.

Background: We retrospectively evaluated the quality of deep learning (DL) reconstructions of on-scanner accelerated intraoperative MRI (iMRI) during respective brain tumor surgery.

Methods: Accelerated iMRI was performed using dual surface coils positioned around the area of resection. A DL model was trained on the fastMRI neuro dataset to mimic the data from the iMRI protocol.

Biaxial flexural strength and surface characterization of multilayer zirconium dioxide after polishing, glazing and clinical adjustments.

Purpose: To evaluate how laboratory polishing and glazing and clinical adjustments, i.e., by grinding and polishing affect the biaxial flexural strength and surface characterization of multilayer zirconia.

Genomic Characteristics Related to Histology-Based Immune Features in Breast Cancer.

The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLS) represent core aspects of antitumor immunity, both increasingly recognized for clinical relevance. In this study, we evaluated immune-related histology features using whole-slide hematoxylin and eosin (H&E) images of The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) data set (n = 1035) and analyzed these distinct features relative to gene expression, PAM50 subtypes, and patient survival.

Food groups, macronutrient intake and objective measures of total carotenoids and fatty acids in 16-to-24-year-olds following different plant-based diets compared to an omnivorous diet.

Background: Knowledge about the diet quality among youth who follow different types of plant-based diets is essential to understand whether support is required to ensure a well-planned diet that meets their nutritional needs. This study aimed to investigate how food groups, macronutrient intake, and objective blood measures varied between Norwegian youth following different plant-based diets compared to omnivorous diet.

Methods: Cross-sectional design, with healthy 16-to-24-year-olds (n = 165) recruited from the Agder area in Norway, following a vegan, lacto-ovo-vegetarian, pescatarian, flexitarian or omnivore diet.

Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake.

Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years.

Dietary sources of free, added, and total sugars in Swedish adolescents.

Purpose: Swedish adolescents' free and added sugars intake exceeds recommended levels. This poses potential health problems; however, little is known about dietary sources within the Swedish population. This study investigated dietary sources of sugars among Swedish adolescents, as well as timing and location of free sugars intake.

'There are healthy things inside': Children's thoughts about, experiences with and approaches to vegetable and fruit consumption.

Children's vegetable and fruit (V&F) consumption is generally lower than dietary recommendations. Thus, this study explored 15 Swedish children's thoughts, experiences and approaches to V&F consumption. Individual interviews were conducted with 10- to 12-year-old children (eight girls and seven boys) of diverse cultural backgrounds.

The effect of different scanning protocols on precision and trueness of intraoral scanning: A pilot trial.

Background: The aim of this study was to investigate how different scanning protocols affect the accuracy (trueness and precision) of intraoral scanning of complete arches with implant cylinders.

Material And Methods: A master model was designed with five cylinders. One scanner, TRIOS2 (3shape), was used to scan the model with four different scan protocols: ROCK (wavelike scanning in a pendulum movement), ZIGZAG (wavelike scanning technique), OBP (occlusal, buccal, and palatal), and OWBP (occlusal, wiggling, buccal, and palatal).

Patient reported experiences of health care, quality of life and preoperative information in colon cancer.

Background And Purpose: Cancer may create problems and needs associated with impaired quality of life (QoL). The first health care encounter is important to enable patients to cope and may ultimately impact QoL. The aim of this study was to describe the patients' experiences of encounters with health care professionals.

Shear Bond Strength of Five Different Repair Systems to Three Different Ceramic Materials.

Purpose: The purpose of the current study was to investigate the shear bond strength of composite resin in five different ceramic repair systems for three different ceramic materials.

Materials And Methods: 225 monolithic zirconia (Zr) and lithium disilicate (LDS) and cobalt chromium (CoCr) specimens with feldspathic porcelain (FP) veneer were fabricated (N=75 per material). The specimens underwent thermo-cycling and were randomly divided into five groups for the following intra-oral repair systems (n=15): 1) Clearfil Ceramic Primer Plus, Kuraray Noritake, Japan; 2) Ibond Intraoral Repair Kit, Kulzer, Germany; 3) VOCO Cimara, VOCO GmbH Germany; 4) Ivoclar Vivadent, Ceramic Repair System Kit, IvoclarVivadent, Liechtenstein; 5) Ultradent Porcelain Repair Kit, Ultradent Products Inc, USA.

BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid Cancer.

Context: BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) have a synergistic effect on prognosis. This effect is believed to arise from MAPK activation triggered by BRAFV600E, leading to the upregulation of ETS transcription factors that bind to the mutant TERT promoter.

Objectives: To explore the role of ETS factors in relation to clinical features, BRAFV600E, and TERT promoter mutations in PTC.

Prognostic genome and transcriptome signatures in colorectal cancers.

Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term follow-up. From the 96 mutated driver genes, 9 were not previously implicated in colorectal cancer and 24 had not been linked to any cancer.

Micronutrient intake and status in young vegans, lacto-ovo-vegetarians, pescatarians, flexitarians, and omnivores.

Purpose: Whether youth who follow plant-based diets in Nordic countries meet their dietary needs for micronutrients remains unclear. This study aims to evaluate micronutrient intake and status in Norwegian youth following vegan, lacto-ovo-vegetarian, pescatarian, flexitarian and omnivore diets.

Methods: Cross-sectional design, with healthy 16-to-24-year-olds (n = 165).

Gothenburg Breast reconstruction (GoBreast) II protocol: a Swedish partially randomised patient preference, superiority trial comparing autologous and implant-based breast reconstruction.

Introduction: Although breast reconstruction is an integral part of breast cancer treatment, there is little high-quality evidence to indicate which method is the most effective. Randomised controlled trials (RCTs) are generally thought to provide the most solid scientific evidence, but there are significant barriers to conducting RCTs in breast reconstruction, making both recruitment and achieving unbiased and generalisable results a challenge. The objective of this study is to compare implant-based and autologous breast reconstruction in non-irradiated patients.

High-frequency, high-intensity TENS compared to standard treatment with opioids for postoperative pain relief after laparoscopic cholecystectomy: A multicentre randomized controlled trial.

Background: Adverse effects of opioids could prolong the duration of stay in the post-anaesthesia care unit (PACU). This study aimed to assess time in the PACU and the pain-relieving effect of high-frequency, high-intensity transcutaneous electrical nerve stimulation (HFHI TENS) versus standard treatment with intravenous (IV) opioids.

Methods: Patients undergoing laparoscopic cholecystectomy at two Swedish hospitals were invited to participate.

Comprehensive genomic analysis of adrenocortical carcinoma reveals genetic profiles associated with patient survival.

Background: Adrenocortical carcinoma (ACC) is one of the most lethal endocrine malignancies and there is a lack of clinically useful markers for prognosis and patient stratification. Therefore our aim was to identify clinical and genetic markers that predict outcome in patients with ACC.

Methods: Clinical and genetic data from a total of 162 patients with ACC were analyzed by combining an independent cohort consisting of tumors from Yale School of Medicine, Karolinska Institutet, and Düsseldorf University (YKD) with two public databases [The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO)].

Genetic variants and down-regulation of CACNA1H in pheochromocytoma.

Pheochromocytoma (PCC) and abdominal paraganglioma (aPGL) (together abbreviated PPGL) frequently present with an underlying genetic event in a PPGL driver gene, and additional susceptibility genes are anticipated. Here, we re-analyzed whole-exome sequencing data for PCC patients and identified two patients with rare missense variants in the calcium voltage-gated channel subunit 1H gene (CACNA1H). CACNA1H variants were also found in the clinical setting in PCC patients using targeted sequencing and from analysis of The Cancer Genome Atlas database.

Standardized evaluation of the extent of resection in glioblastoma with automated early post-operative segmentation.

Standard treatment of patients with glioblastoma includes surgical resection of the tumor. The extent of resection (EOR) achieved during surgery significantly impacts prognosis and is used to stratify patients in clinical trials. In this study, we developed a U-Net-based deep-learning model to segment contrast-enhancing tumor on post-operative MRI exams taken within 72 h of resection surgery and used these segmentations to classify the EOR as either maximal or submaximal.

The effect of combining primers and cements from different cement systems on the bond strength between zirconia and dentin.

Objective: The aim of this study was to evaluate the influence of combining primers and cements from two different resin cement systems on the microtensile bond strength (μTBS) between zirconia and human dentin.

Materials And Methods: A total of 120 specimens of zirconia cemented to dentin were allocated into eight groups based on cement type (RelyX Ultimate or Panavia V5) and primers (Tooth Primer, Clearfil Ceramic Primer and Scotchbond Universal Adhesive) combinations, applied to dentin or ceramic surfaces. Following artificial aging with 5000 thermocycles, μTBS tests were conducted.

A systematic review of randomised controlled trials in breast reconstruction.

Background: For preference sensitive treatments, such as breast reconstructions, there are barriers to conducting randomised controlled trials (RCTs). The primary aims of this systematic review were to investigate what type of research questions are explored by RCTs in breast reconstruction, where have they been performed and where have they been published, and to thematise the research questions and thus create an overview of the state of the research field.

Methods: Randomised controlled trials investigating any aspect of breast reconstructions were included.

Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study.

Somatic and biallelic DICER1 mutations are reported in subsets of thyroid tumors, supporting the role of this gene in thyroid tumor development. As recent studies have brought attention to macrofollicular patterns, atrophic changes, and papillary structures as being associated with DICER1 mutations, we sought to explore these observations in a bi-institutional cohort. A total of 61 thyroid lesions (54 tumors and 7 cases of thyroid follicular nodular disease; TFND), including 26 DICER1 mutated and 35 DICER1 wildtype controls were subjected to histological re-investigation and clinical follow-up.