[Pathological status of catecholamines in the corpus striatum in hepatocerebral dystrophy (Wilson-Konovalov disease)].

The content of catecholamines in the striatum was measured in 2 patients suffering from hepatocerebral dystrophy (Wilson-Konovalov disease). It is noted that in different clinical manifestations of the disease, the changes in the content of noradrenaline in the striatum varied. A male patient with marked tremor spreading manifested a considerable rise of the content of catecholamines, primarily in the n.

[A micromodification of the method of determining the activity of processes of free radical oxidation].

A micromodification of the method for registration of bivalent iron ion-initiated chemiluminescence of the apo-beta-lipoprotein total fraction isolated from the blood serum is described. A significant elevation of lipid peroxide levels and of lipid ability to oxidation, paralleled by reduced levels of endogenous antioxidants as against the norm were revealed in the patients with acute disorders of brain circulation with the use of this method. Chemiluminescent studies of lipid peroxidation processes permit monitoring lipid peroxidation reactions and thus obtain a complex of parameters that characterize the status of these processes in the studied system.

[Catecholamine metabolism in extrapyramidal disorders in patients with chronic hypertensive encephalopathy].

Total and cerebral metabolism of catecholamines (CA) was examined in patients with associated chronic hypertonic encephalopathy and extrapyramidal disorders. It was discovered for the first time that there was an increase in noradrenaline in the blood and cerebrospinal fluid together with a lowering of the content of dopamine and major metabolite thereof along the pathway of oxidative deamination of homovanillic acid. CA metabolism was shown to correlate with the patients' age, duration and gravity of extrapyramidal disorders.

[Endogenous toxemia in acute disorders of cerebral circulation].

Critical conditions that develop because of hypoxia of different genesis are accompanied by endogenous intoxication induced to a considerable degree by the appearance in the blood of an excess amount of medium-sized molecules (MSM). An appreciable increase of the content of MSM was demonstrated since the very first days after the brain stroke as a result of examining 100 patients who suffered brain stroke, including 83 patients during the first week of the disease and 17 patients of the reference group with a history of acute impairment of cerebral circulation which had occurred over a month before. A reverse correlation was established between the level of endogenous intoxication and the clinical status of the patients which could be observed every day during the acute disease phase.

[A comparative evaluation of the efficacy of methods of determining osmolality and middle molecules in the prognosis of the course of strokes].

The authors compare the efficacies of methods for assessing osmolality (OSM) and analysis of medium molecules (MM) in the prediction of the post-stroke period course in the first 7 days from the stroke onset. Prognostically unfavorable MM and OSM values were found, predicting the possible lethal outcome. On the whole the MM index was found 1.

[Analysis of trace elements of the brain and liver tissues in Wilson's disease].

In a patients with extrapyramidal-cortical form of the Wilson-Konovalov disease, brain and liver tissues were tested for Ca, Cu, Fe, Ka, Mg, Mn, Mo, P, Pb, Se, Sn, Sz, Zn, S, using plasma emission spectrometry. The tissues autopsied from 2 cerebral hemorrhage victims served as controls. Hepatic Cu concentration was increased 24-fold (6.

[Ceruloplasmin activity in the blood during progressive diseases of the central nervous system].

Ceruloplasmin (CP) preparations have been used as the reference agents in transition of this protein oxidase activity to blood serum concentrations; the mean concentrations of serum CP varied from 175 to 310 mg/l, depending on the biochemical characteristics of the preparations. Adjustment by the blood serum copper level has proved adequate for clinical studies. CP activity has been found increased in some patients with disseminated sclerosis and lateral amyotrophic sclerosis.

[Use of a conductometric detector in capillary isotachophoresis of blood serum proteins].

Conductometric detectors can be employed for analysis of the blood serum proteins. Conductometric curves of various sera show at least 12 peaks corresponding to certain protein fractions and inorganic components. Isotachophoresis of individual protein preparations detects impurities in them.

[Analysis of the composition of the microelements in the hair of normal subjects and in disseminated sclerosis].

The modification of analysis of the hair trace elements involves hair dissolution in nitric acid and analysis of the iron, manganese, and copper by flameless atomic-absorption spectrometry and of zinc by the flame technique. Trace element content has been measured in the hair of 26 normal subjects aged 20-50 and of 20 children. In adults iron, manganese, zinc, and copper concentrations were 12.

[Cyclic nucleotides in multiple sclerosis].

The authors studied concentrations of cyclic nucleotides (cAMP and cGMP), as well as their ratio in the blood plasma and cerebrospinal fluid (CSF) of 83 patients with disseminated sclerosis of different forms and variants. An elevation in cAMP concentrations in the plasma and CSF detected in all the patients was more expressed in cases of a long standing and disseminated process. Blood levels of cAMP showed greater variability in the period of exacerbation versus remission of the disease.

[Endogenous morphines in chronic progressive diseases of the central nervous system].

Using radioimmunoassay the authors studied concentrations of beta-endorphine and metenkephalin in the cerebrospinal fluid (CSF) of 65 patients with various diseases of the central nervous system (CNS)--hereditary extrapyramidal disorders, disseminated sclerosis (DS), lateral amyotrophic sclerosis (LAS), spinal tumours, senile dementia, some CNS impairments of inflammatory nature. Patients with spinal tumours showed a 4-14-fold elevation in metenkephalin levels along with a comparatively high content of beta-endorphine. In senile dementia, the concentration of both peptides was lowered.

[Several biochemical mechanisms of the pathogenesis of Huntington chorea].

Parameters of catecholamine and acetylcholine metabolism were investigated in 55 patients with Huntington's chorea. Heterogeneous nature of the results obtained by examining excretion of catecholamines, their precursors, and metabolites appears to reflect varying degrees of the damage to the cerebral neurotransmitter systems and their imbalance in different patients. It is suggested that the level of catecholamine metabolism in the body is genetically determined.

[Initial antibiotic resistance of the microflora isolated in various pathological states].

Composition of microflora was studied in complicated wound infections and some inflammatory diseases. The comparative characteristics of the antibiotic resistance of the isolates is presented. It was noted that Pseudomonas and Proteus predominated in the microflora isolated in complicated wound infections.