[New techniques for optimization of thiopurine therapy in leukemia and transplantation].

Background: The majority of chemotherapeutic agents are administered at fixed doses that are close to those maximally tolerated.

Material And Methods: This review is based on current knowledge about the metabolism of thiopurines and the clinical implications of genetic polymorphism in thiopurine-S-methyltransferase (TPMT).

Results: Intracellularly thiopurines, e.