Studies on a Gastric inhibitory Substance Isolated from Juice of the Gastric Antrum in the Dog.

Six mongrel dogs were prepared with vagally denervated antral pouches and Heidenhain fundic poucnes. An extract was prepared from juice secreted by the antrum by dialyzing against water and lyophilization. This gastric inhibitory substance (GIS) was assayed in the dog from which it was prepared.

Magnesium, Calcium, and Inorganic Phosphorus in Gastrin-Stimulated Gastric Secretion of Man.

Gastrin Leo was injected subcutaneously (2 μg/kg body weight) in 10 patients on 19 occasions, and the gastric juice was aspirated continuously for 1 hour before and 1 hour after the injection. The gastric juice was divided into 20-minute portions and analysed for volume and content of TA, K, Na, Mg, Ca, and P. Concentrations ([ ]) of TA, K, and Mg increased after injection of gastrin, while [Na], [Ca] and [P] decreased.