Automated estimation of salvageable tissue: Comparison with expert readers.

Purpose: To assess the performance of an automatic perfusion-diffusion mismatch outlining algorithm, in a cohort of acute ischemic stroke patients imaged as part of a multicenter study.

Materials And Methods: Magnetic resonance imaging (MRI) from 167 patients with anterior circulation strokes scanned at either 3T or 1.5T systems were analyzed retrospectively through an automatic perfusion-diffusion mismatch detection algorithm.

Biased visualization of hypoperfused tissue by computed tomography due to short imaging duration: improved classification by image down-sampling and vascular models.

Objectives: Lesion detection in acute stroke by computed-tomography perfusion (CTP) can be affected by incomplete bolus coverage in veins and hypoperfused tissue, so-called bolus truncation (BT), and low contrast-to-noise ratio (CNR). We examined the BT-frequency and hypothesized that image down-sampling and a vascular model (VM) for perfusion calculation would improve normo- and hypoperfused tissue classification.

Methods: CTP datasets from 40 acute stroke patients were retrospectively analysed for BT.

Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial.

Background And Purpose: Remote ischemic preconditioning is neuroprotective in models of acute cerebral ischemia. We tested the effect of prehospital rPerC as an adjunct to treatment with intravenous alteplase in patients with acute ischemic stroke.

Methods: Open-label blinded outcome proof-of-concept study of prehospital, paramedic-administered rPerC at a 1:1 ratio in consecutive patients with suspected acute stroke.

Acute stroke: automatic perfusion lesion outlining using level sets.

Purpose: To develop a user-independent algorithm for the delineation of hypoperfused tissue on perfusion-weighted images and evaluate its performance relative to a standard threshold method in simulated data, as well as in acute stroke patients.

Materials And Methods: The study was approved by the local ethics committee, and patients gave written informed consent prior to their inclusion in the study. The algorithm identifies hypoperfused tissue in mean transit time maps by simultaneously minimizing the mean square error between individual and mean perfusion values inside and outside a smooth boundary.

Lipid content in the musculature of the lower leg: evaluation with high-resolution spectroscopic imaging.

A novel spectroscopic imaging method with high spectral and spatial resolution was developed for the specific goal of assessing muscle fat. Sensitivity to the methylene and methyl protons of fatty acids was improved by the use of a binomial 1 1 excitation pulse instead of the standard radiofrequency (RF) pulse. Acceptable measurement time is achieved by using a narrow spectral bandwidth (6 ppm).