Publications by authors named "Lars Oliver Baumbusch"
Article Synopsis
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Article Synopsis
- Birth asphyxia is a leading cause of mortality and disability in children globally, with long non-coding RNAs (lncRNAs) presenting potential targets for new treatments due to their regulatory functions.
- A study using piglets examined key lncRNAs involved in oxidative stress and related processes, dividing 42 newborn subjects across four experimental conditions including varying reoxygenation methods after hypoxia.
- Results showed that exposure to hypoxia significantly affected lncRNA transcription levels, suggesting that these molecules play a crucial role in the brain's response to damage from perinatal asphyxia and could lead to future therapeutic strategies.
Background: Since the discovery more than half a century ago, cell-free DNA (cfDNA) has become an attractive objective in multiple diagnostic, prognostic, and monitoring settings. However, despite the increasing number of cfDNA applications in liquid biopsies, we still lack a comprehensive understanding of the nature of cfDNA including optimal assessment. In the presented study, we continued testing and validation of common techniques for cfDNA extraction and quantification (qRT-PCR or droplet digital PCR) of nuclear- and mitochondrial cfDNA (ncfDNA and mtcfDNA) in blood, using a piglet model of perinatal asphyxia to determine potential temporal and quantitative changes at the levels of cfDNA.
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- Neuroblastoma (NBL) is a highly variable childhood cancer with outcomes ranging from spontaneous recovery to severe progression, and there's a need for better prognostic and therapeutic strategies.
- Researchers conducted whole exome sequencing on tumor samples from 18 NBL patients, identifying key mutations in known genes like ALK and additional variants in several other cancer-related genes.
- The study also unearthed novel coding variants in nine important genes potentially linked to NBL, enhancing our understanding of the disease's biology and progression in high-risk cases.
Cell free DNA (cfDNA) in plasma has been described as a potential diagnostic indicator for a variety of clinical conditions, including neonatal hypoxia. Neonatal hypoxia or perinatal asphyxia is a severe medical condition caused by a temporary interruption in oxygen availability during birth. Previously, we have reported temporal changes of cfDNA detected in blood in a newborn piglet model of perinatal asphyxia.
View Article and Find Full Text PDFPerinatal asphyxia is a severe medical condition resulting from oxygen deficiency (hypoxia) at the time of birth, causing worldwide approximately 680,000 newborn deaths every year. Better prediction of severity of damages including early biomarkers is highly demanded. Elevated levels of circulating cell-free DNA (cfDNA) in blood have been reported for a range of different diseases and conditions, including cancer and prematurity.
View Article and Find Full Text PDFGenomic copy number alterations are common in cancer. Finding the genes causally implicated in oncogenesis is challenging because the gain or loss of a chromosomal region may affect a few key driver genes and many passengers. Integrative analyses have opened new vistas for addressing this issue.
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