Publications by authors named "Lars McNaughton"

Enhanced buffering capacity following sodium citrate (SC) ingestion may be optimized when subsequent exercise commences at individual time-to-peak (TTP) alkalosis (blood pH or bicarbonate concentration [HCO3-]). While accounting for considerable interindividual variation in TTP (188-300 min), a reliable blood alkalotic response is required for practical use. This study evaluated the reliability of blood pH, HCO3-, and sodium (Na+) following acute SC ingestion.

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  • The study looked at how different people's muscles reacted to two types of exercise: resistance training and high-intensity interval training, over 12 weeks.
  • Researchers measured the thickness of a specific muscle (rectus femoris) in 440 adults using ultrasound and found that everyone's muscles grew differently.
  • They discovered some genetic factors that might affect how muscles respond to exercise, and created models to help predict how much someone's muscles could grow based on these factors.
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  • Oxidative stress significantly contributes to neurodegeneration, cognitive decline, and aging, but antioxidant use, particularly astaxanthin, may offer protective benefits.
  • Astaxanthin, a strong antioxidant, has shown promise in enhancing cognitive function in both lab studies and human research, prompting further investigation into its effects on human populations.
  • The review highlights astaxanthin’s potential to improve cognitive abilities and provide neuroprotection, while discussing its implications, research limitations, and future study opportunities.
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  • Sodium bicarbonate (SB) has been primarily studied for its effects on short-duration high-intensity exercise, but this study aims to explore its impact before prolonged high-intensity activities, specifically a 16.1-km cycling time trial.
  • Ten trained male cyclists participated in a randomized crossover design, where they ingested SB in two forms (gelatin and enteric capsules) and a placebo, assessing their performance in the cycling trials.
  • Results showed significant improvements in performance times with SB ingestion compared to placebo, particularly with enteric capsules having fewer gastrointestinal issues, suggesting SB can enhance endurance cycling performance.
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  • Sodium bicarbonate (SB) supplementation was studied for its effect on 2 km rowing performance in female CrossFit athletes, finding that it notably improved race times by 2.24% compared to a placebo.
  • The study involved 11 female athletes who ingested SB or a placebo in a randomized crossover design, with an average time to peak bicarbonate levels occurring about 102 minutes post-ingestion.
  • Results showed a significant correlation between increased blood bicarbonate levels and performance improvement, indicating SB's potential as an effective ergogenic aid for female athletes.
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  • Extracellular buffering agents like sodium bicarbonate, sodium citrate, and sodium/calcium lactate are studied for their potential to enhance exercise performance, though factors influencing their effectiveness are still debated.
  • A systematic review analyzing 189 studies showed that these supplements significantly raised blood bicarbonate levels and improved exercise capacity, particularly for activities lasting between 0.5 to 10 minutes and over 10 minutes.
  • The study also noted that the extent of blood bicarbonate increase impacts performance; larger increases (above 4 mmol L) correlated with better exercise outcomes compared to smaller increases.
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Introduction: Physeal injuries have been overlooked in epidemiological research in youth sports. Our prospective study investigated the incidence, severity, and burden of physeal injuries in a youth elite football academy.

Methods: In total, 551 youth male football players from under-9 to under-19 were included and observed over four consecutive seasons.

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As a nitric oxide (NO) enhancer, citrulline malate (CM) has recently been touted as a potential ergogenic aid to both resistance and high-intensity exercise performance, as well as the recovery of muscular performance. The mechanism has been associated with enhanced blood flow to active musculature, however, it might be more far-reaching as either ammonia homeostasis could be improved, or ATP production could be increased via greater availability of malate. Moreover, CM might improve muscle recovery via increased nutrient delivery and/or removal of waste products.

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  • The optimal timing for sodium bicarbonate (NaHCO3) supplementation might align with individual peak levels of bicarbonate or pH in the blood, but the effectiveness of this strategy is debated.
  • Research involving twelve adolescent swimmers examined changes in blood bicarbonate, pH, and strong ion difference (SID) after ingesting NaHCO3, revealing no significant differences in peak times for these measures.
  • Notably, a large effect size suggested that the timing of bicarbonate peaks may differ from SID, indicating a need for further studies comparing these personalized strategies to standard supplementation approaches.
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Background: The association between injury risk and skeletal maturity in youth soccer has received little attention.

Purpose: To prospectively investigate injury patterns and incidence in relation to skeletal maturity in elite youth academy soccer players and to determine the injury risks associated with the skeletal maturity status, both overall and to the lower limb apophysis.

Study Design: Descriptive epidemiology study.

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Sodium bicarbonate (SB) is considered an effective ergogenic supplement for improving high-intensity exercise capacity and performance, although recent data suggests that women may be less amenable to its ergogenic effects than men. Currently, an apparent paucity of data on women means no consensus exists on whether women benefit from SB supplementation. The aim of the current study was to quantify the proportion of the published literature on SB supplementation that includes women, and to synthesise the evidence regarding its effects on blood bicarbonate and exercise performance in women by performing a systematic review and meta-analysis.

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Objective: Investigate the incidence and burden of injuries by age group in youth football (soccer) academy players during four consecutive seasons.

Methods: All injuries that caused time-loss or required medical attention (as per consensus definitions) were prospectively recorded in 551 youth football players from under 9 years to under 19 years. Injury incidence (II) and burden (IB) were calculated as number of injuries per squad season (s-s), as well as for type, location and age groups.

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Objectives: This study aimed to investigate whether supplementation with 12 mg⋅day astaxanthin for 7 days can improve exercise performance and metabolism during a 40 km cycling time trial.

Design: A randomised, double-blind, crossover design was employed.

Methods: Twelve recreationally trained male cyclists (VO: 56.

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 In the elderly, low protein intake exacerbates the effects of sarcopenia and anabolic resistance.  Protein supplementation to maximise muscle protein synthesis, may be an effective intervention. Aim: To determine the effects of a low/high dose of protein, ingested immediately post-exercise, during resistance training in novice elderly males.

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Purpose: Enteric-coated sodium bicarbonate (NaHCO) can attenuate gastrointestinal (GI) symptoms following acute bicarbonate loading, although the subsequent effects on exercise performance have not been investigated. The purpose of this study was to examine the effects of enteric-coated NaHCO supplementation on high-intensity exercise performance and GI symptoms.

Methods: Eleven trained male cyclists completed three 4 km time trials after consuming; a placebo or 0.

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Enteric-formulated capsules can mitigate gastrointestinal (GI) side effects following sodium bicarbonate (NaHCO3) ingestion; however, it remains unclear how encapsulation alters postingestion symptoms and acid-base balance. The current study aimed to identify the optimal ingestion form to mitigate GI distress following NaHCO3 ingestion. Trained males (n = 14) ingested 300 mg/kg body mass of NaHCO3 in gelatin (GEL), delayed-release (DEL), and enteric-coated (ENT) capsules or a placebo in a randomized cross-over design.

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  • The study investigated how post-exercise ingestion of sodium bicarbonate (NaHCO) affects acid-base balance recovery and exercise performance in elite boxers.
  • Seven male professional boxers completed high-intensity exercise followed by recovery, where they ingested either NaHCO or sodium chloride (PLA) in a double-blind setup.
  • Results showed significant improvements in recovery (higher pH and performance) following NaHCO compared to PLA, suggesting its potential as a recovery aid for athletes in combat sports.
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Background: Sodium bicarbonate (NaHCO) is a well-established nutritional ergogenic aid, though gastrointestinal (GI) distress is a common side-effect. Delayed-release NaHCO may alleviate GI symptoms and enhance bicarbonate bioavailability following oral ingestion, although this has yet to be confirmed.

Methods: In a randomised crossover design, pharmacokinetic responses and acid-base status were compared following two forms of NaHCO, as were GI symptoms.

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This study investigated the effects of two separate doses of sodium bicarbonate (NaHCO) on 4 km time trial (TT) cycling performance and post-exercise acid base balance recovery in hypoxia. Fourteen club-level cyclists completed four cycling TT's, followed by a 40 min passive recovery in normobaric hypoxic conditions (FiO = 14.5%) following one of either: two doses of NaHCO (0.

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Research has outlined how self-regulation is crucial to the decision-making processes and pacing of endurance performance. There is evidence to suggest that executive function is implicated in self-regulatory processes, as the two are conceptually similar and share common brain regions such as the prefrontal cortex. This review draws upon various research domains to argue that executive function underlies the top-down self-regulation of endurance tasks.

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Eccentric hamstring strength is an aetiological risk factor for soccer injury. The temporal pattern of recovery post-exercise is critical in injury management. 18 male professional soccer players completed baseline assessments of eccentric hamstring strength at isokinetic speeds of 60, 150 and 300°· s.

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  • The study explored how sodium bicarbonate (NaHCO) affects cycling performance and recovery in hypoxic conditions, which are known to increase fatigue due to hydrogen ion production.
  • Ten trained male cyclists participated in time trials after ingesting different doses of NaHCO or a placebo, revealing that a dosage of 0.3 g/kg body mass led to significant performance improvements over the placebo.
  • The findings suggest that consuming NaHCO can enhance exercise capability in low oxygen environments, with the 0.3 g/kg dose being the most beneficial for performance.
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This investigation assessed the effect of dietary nitrate (NO) supplementation, in the form of beetroot juice (BR), on repeat-sprint performance in normoxia and normobaric hypoxia. 12 male team-sport athletes (age 22.3 ± 2.

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Blood alkalosis, as indicated by an increased blood bicarbonate concentration and pH, has been shown to be beneficial for exercise performance. Sodium bicarbonate, sodium citrate, and sodium or calcium lactate, can all result in increased circulating bicarbonate and have all independently been shown to improve exercise capacity and performance under various circumstances. Although there is considerable evidence demonstrating the efficacy of these supplements in several sports-specific situations, it is commonly acknowledged that their efficacy is equivocal, due to contrasting evidence.

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