Publications by authors named "Lars Maurer"
Current culture systems available for studying hepatitis D virus (HDV) are suboptimal. In this study, we demonstrate that hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) are fully permissive to HDV infection across various tested genotypes. When co-infected with the helper hepatitis B virus (HBV) or transduced to express the HBV envelope protein HBsAg, HLCs effectively release infectious progeny virions.
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- HEV (hepatitis E virus) infects people and can trigger a response from special immune cells called CD4 T cells, which help fight the virus and make antibodies.
- Researchers studied these CD4 T cells and antibodies to better understand their roles in people with HEV infections.
- They found that the main target for these immune cells is a part of the virus called the capsid, and while antibodies against the virus are strong at first, they decrease over time.
The hepatitis E virus (HEV) is a major global health problem, leading to large outbreaks in the developing world and chronic infections in the developed world. HEV is a non-enveloped virus, which circulates in the blood in a quasi-enveloped form. The quasi-envelope protects HEV particles from neutralising anti-capsid antibodies in the serum; however, most vaccine approaches are designed to induce an immune response against the HEV capsid.
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