Publications by authors named "Lars Matthias Ittner"
Article Synopsis
- Cyclotides are stable cyclic peptides with potential to protect neurons in neurological disorders by modifying their structure for better delivery.
- The study involved enhancing the cyclotide MCoTI-II with polyarginines and inserting an NMDA receptor inhibitor sequence, which improved neuronal uptake and prevented cell death from excitotoxicity.
- In tests, the modified cyclotide (c5R-NR2B9c) not only protected primary neurons but also increased survival and reduced seizure severity in a mouse model, indicating its potential as a therapeutic strategy.
Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular aggregates of hyperphosphorylated tau (FTLD-tau). Moreover, genetic studies identified mutations in the MAPT gene encoding tau in familial cases of the disease. In this review, we cover a range of aspects of tau function, both in the healthy and diseased brain, discussing several in vitro and in vivo models.
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