Publications by authors named "Lars Kjelsberg Pedersen"
Article Synopsis
- Gliomas are diverse tumors, and accurately identifying aggressive areas and borders is crucial for diagnosis and treatment; this study explored the use of [F]-FACBC PET for better glioma tissue classification.
- The research involved analyzing pre-surgical [F]-FACBC PET/MR images and comparing their effectiveness with histomolecular results and conventional MRIs through biopsy samples from 17 patients with various glioma grades.
- Findings indicated that [F]-FACBC PET outperformed conventional MRI in sensitivity and specificity for tumor classification, revealing larger tumor volumes in glioblastoma patients and showing potential for improved diagnostic accuracy when used alongside traditional MRI methods.
Diagnostic accuracy of anti-3-[F]-FACBC PET/MRI in gliomas.
Eur J Nucl Med Mol Imaging
January 2024
Purpose: The primary aim was to evaluate whether anti-3-[F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.
Methods: In this prospective study, patients with suspected primary or recurrent gliomas were recruited from two sites in Norway and examined with PET/MRI prior to surgery.
Objective: We analyzed data from the Norwegian Stroke Registry (NSR) to study access to and outcomes of decompressive hemicraniectomy for brain infarction in a nationwide routine clinical setting. We also discretionary assessed whether the outcomes were comparable with those achieved in randomized controlled trials (RCTs), and whether the use was in accordance with guidelines.
Methods: The NSR is a nationwide (population 5.
Purpose: The study aims to evaluate whether combined 18 F-FACBC PET/MRI could provide additional diagnostic information compared with MRI alone in brain metastases.
Patients And Methods: Eighteen patients with newly diagnosed or suspected recurrence of brain metastases received dynamic 18 F-FACBC PET/MRI. Lesion detection was evaluated on PET and MRI scans in 2 groups depending on prior stereotactic radiosurgery (SRS group) or not (no-SRS group).
Objective: IDH-mutant diffuse low-grade gliomas (dLGGs; WHO grade 2) are often considered to have a more indolent course. In particular, in patients with 1p19q codeleted oligodendrogliomas, survival can be very long. Therefore, extended follow-up in clinical studies of IDH-mutant dLGG is needed.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to develop a prognostic model specifically for predicting the success of endoscopic third ventriculostomy (ETV) in adult patients with hydrocephalus, addressing the need for adult-specific outcomes as current research primarily focuses on children.
- It involves a retrospective examination of ETV patients aged 18 and older from 2010 to 2018, utilizing univariate and multivariate analyses to identify predictors of success.
- The findings aim to enhance patient selection for ETV and inform decision-making, potentially reducing the need for additional procedures due to treatment failure.
Background: Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected "high-risk" patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in diagnostic work-up and treatment between treating centers in 2 Scandinavian countries with similar public health care systems.
View Article and Find Full Text PDFTriple Use of Autologous Amnion Graft in the Treatment of Meningomyelocele and Split Cord Malformation.
Plast Reconstr Surg Glob Open
January 2020
This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mechanical barrier to protect the myelomeningocele (MMC) from desiccation and mechanical stress directly after birth. A second graft was used as a dura substitute to close the cerebrospinal fluid compartment.
View Article and Find Full Text PDF