Publications by authors named "Lars B Leibrock"

inhalation toxicology methods are increasingly being used for research and regulatory purposes. Although the opportunity for increased human relevance of inhalation methods compared to tests has been established and discussed, how to systematically account for variability and maximize the reliability of these methods, especially for assays that use cells cultured at an air-liquid interface (ALI), has received less attention. One tool that has been used to evaluate the robustness of test methods is cause-and-effect (C&E) analysis, a conceptual approach to analyze key sources of potential variability in a test method.

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Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising method to supplement studies. ALI exposure reflects the physiological conditions of the deep lung more closely to subacute inhalation scenarios compared to submerged exposure. The comparability of the toxicological results obtained from and inhalation data is still challenging.

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