Publications by authors named "Larry T Enderby"
Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis.
J Pineal Res
April 2018
The Melatonin Osteoporosis Prevention Study (MOPS) demonstrated that nightly melatonin resulted in a time-dependent decrease in equilibrium ratios of serum osteoclasts and osteoblasts in perimenopausal women. This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using coculture models (transwell or layered) of human mesenchymal stem cell (MSC) and human peripheral blood monocytes (PBMCs). Human MSC/PBMC cocultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered cocultures did melatonin inhibit osteoclastogenesis.
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- A one-year trial tested the combination of melatonin, strontium, vitamin D3, and vitamin K2 (MSDK) on bone health in postmenopausal women with low bone density.
- Compared to a placebo, MSDK treatment significantly improved bone mineral density in the lumbar spine and femoral neck while also enhancing mood and sleep quality in participants.
- The study found that MSDK influenced cellular processes related to bone formation and resorption, suggesting it could be beneficial for preventing or treating conditions like osteopenia and osteoporosis.
Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women.
J Pineal Res
May 2012
The purpose of this double-blind study was to assess the effects of nightly melatonin supplementation on bone health and quality of life in perimenopausal women. A total of 18 women (ages 45-54) were randomized to receive melatonin (3mg, p.o.
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