Randomized double-blind clinical trial of subcutaneously injected deoxycholate versus a phosphatidylcholine-deoxycholate combination for the reduction of submental fat.

Background: Subcutaneous injections consisting of the detergent, sodium deoxycholate, alone or in combination with the phospholipid, phosphatidylcholine, have been reported to reduce adipose tissue. The role of phosphatidylcholine remains unclear.

Objective: To evaluate the safety profile and efficacy of subcutaneously injected deoxycholate alone compared with a conventionally utilized mixture of phosphatidylcholine/deoxycholate in patients with undesirable accumulations of submental fat.