Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response.

Multiple sclerosis (MS) results in inflammatory damage to white matter microstructure. Prior research using blood-oxygen-level dependent (BOLD) imaging indicates MS-related alterations to brain function. What is currently unknown is the extent to which white matter microstructural damage influences BOLD signal in MS.

Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis.

Objective: Cognitive slowing is a core neuropsychological symptom of Multiple Sclerosis (MS). We aimed to assess the extent to which cognitive slowing in MS was predicted by changes in dorsolateral prefrontal networks.

Method: We assessed patients with relapsing-remitting MS and healthy controls (HCs) on measures of processing speed.