Characterization of a mouse model of islet transplantation using MIN-6 cells.

Immortalized beta cells are an abundant source of insulin-producing cells. Although MIN-6 cells have similar characteristics as normal islets , the use of MIN-6 cells has not been fully described. This study characterizes mouse models of MIN-6 transplantation and rejection.

Interferon-tau inhibits the development of diabetes in NOD mice.

Interferon-alpha (IFN-alpha) inhibits the development of diabetes in animal models of autoimmune diabetes. However, the mechanism of the action is not fully understood and drug toxicity could limit its potential clinical utility. Interferon-tau (IFN-tau) is another type 1 interferon, which has less toxicity but may have different biologic activity than IFN-alpha.