NAPQI is absent in the mouse brain after Sub-hepatotoxic and hepatotoxic doses of acetaminophen.

Acetaminophen (APAP) is the most-used over-the-counter analgesic among pregnant women. However, concerns have arisen over the safety of APAP exposure during gestation. In particular, it's been speculated that the hepatotoxic metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), forms in the brain after maternal use of therapeutic APAP doses and leads to neurodevelopmental disorders (NDDs).

Reducing perceived pain levels during nonbreast lymphoscintigraphy.

Purpose: The aim of this study was to quantify the reduction of perceived pain levels during lymphoscintigraphy for melanoma by altering the pH of the Tc-sulfur colloid to near the physiologic value of 7.40.

Patients And Methods: This is an institutional review board- and Food and Drug Administration-approved randomized, double-blinded, prospective crossover trial, registered with clinicaltrials.