Biological activity of Morita-Baylis-Hillman adduct homodimers in L. infantum and L. amazonensis: anti-Leishmania activity and cytotoxicity.

This study is a report on the anti-Leishmania activity of Morita-Baylis-Hillman (MBH) homodimers adducts against the promastigote and axenic amastigote forms of Leishmania (Leishmania) infantum and Leishmania (Leishmania) amazonensis and on the cytotoxicity of these adducts to human blood cells. Both studied homodimers, MBH 1 and MBH 2, showed activity against the promastigote forms of L. infantum and L.

Anti- and cytotoxic activities of perillaldehyde epoxide synthetic positional isomers.

Leishmaniasis belongs to a complex of zoonotic disease caused by protozoa of the genus and is considered a major public health problem. Several essential oil chemical components have inhibitory effect against protozoa, including . Thus, the aim of this study was to evaluate for the first time the anti- activity of two -menthane monoterpene isomers (EPER-1: perillaldehyde 1,2-epoxide and EPER-2: perillaldehyde 8,9-epoxide) against promastigotes as well as evaluating cytotoxic effect on mononuclear peripheral blood cells.