Publications by authors named "Larissa Zatorre Almeida Lugo"
Persistent human papillomavirus (HPV) infection is closely associated with cervical carcinoma. Co-infection in the endocervical environment with other microorganisms, such as Chlamydia trachomatis, may increase the risk of HPV infection and neoplastic progression. While in some individuals, Chlamydia trachomatis infection is resolved with the activation of Th1/IFN-γ-mediated immune response, others develop a chronic infection marked by Th2-mediated immune response, resulting in intracellular persistence of the bacterium and increasing the risk of HPV infection.
View Article and Find Full Text PDFPersistent infection by high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer and its precursor lesions. While some cytokines help immune cells in virus clearance, others contribute to the persistence of infection and neoplastic progression. Here, the levels of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-10, IL-6, IL-4, and IL-2 were quantified in the serum and exfoliated cervical cells (ECCs) of patients with HR-HPV, and the presence of IL-6+ cells was investigated in uterine cervix biopsies.
View Article and Find Full Text PDFHuman Papillomavirus (HPV) has considerable tropism for epithelial and mucosal tissues and can therefore be found in several anatomical sites, including the oral cavity. This study aimed to investigate the presence of HPV-DNA and the most frequent viral types in patients using full dentures, compare to patients not using full dentures and to associate its presence with socio-epidemiological and behavioral factors. The study consisted of 90 patients with or without full dentures at the time of collection, treated at a public dental clinic.
View Article and Find Full Text PDFArticle Synopsis
- Persistent infection with high-risk HPV is a major cause of cervical cancer, and the immune response, particularly involving IL-17 and Th17 cells, plays a key role in managing infection.* -
- The study measured IL-17 levels in the serum and cervical cells of 26 HR-HPV-infected patients and 18 healthy individuals, finding significantly higher IL-17 concentrations in HR-HPV-positive patients.* -
- Despite higher systemic IL-17 levels in HR-HPV-infected patients, there were no significant differences in CD4IL-17 cell counts across various cervical lesions, indicating a more systemic than localized immune response.*
Purpose Of Review: Cervical cancer, the third cause of death by cancer among Brazil's women, is associated with human papillomavirus (HPV) infection. In some countries of South America, North America, Europe, and Oceania, initial screening for HPV DNA and subsequent follow-up with HPV-positive patients using colposcopy and cytological testing are used as preventative measures.
Recent Findings: For HPV DNA detection, it is necessary to obtain cervical cells by conventional clinical collection method or self-collection of the cells that flake off from the uterine cervix and vaginal canal.