Publications by authors named "Larissa Stefhanne Damasceno Amorim"
Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis.
J Oral Pathol Med
April 2022
Background: Fibrous dysplasia (FD) and cemento-ossifying fibroma (COF) are the most common gnathic fibro-osseous lesions. These diseases exhibit remarkable overlap of several clinicopathological aspects, and differential diagnosis depends on the combination of histopathological, radiographic, and clinical aspects. Their molecular landscape remains poorly characterized, and herein, we assessed their proteomic and phosphoproteomic profiles.
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- Head and neck cancers, particularly oral squamous cell carcinoma (OSCC), are common worldwide and have a poor prognosis, often linked to complex genetic and metabolic changes.
- This review focuses on metabolomics—the study of small molecules in biological processes—to analyze OSCC and premalignant conditions, aiming to clarify the oral cancer development process and identify potential metabolic biomarkers.
- Despite some insights from current metabolomic studies, there's a need for further research and validation to effectively apply these findings in clinical settings.
Oral pyogenic granulomas show MAPK/ERK signaling pathway activation, which occurs independently of BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations.
J Oral Pathol Med
November 2019
Background: Pyogenic granuloma (PG) is a benign nodular lesion with a prominent vascular component which may affect different sites. Recently, BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations were reported on PGs of the skin. The present study assessed the role of the MAPK/ERK pathway in oral PG pathogenesis.
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