Publications by authors named "Larissa Spiegelberg"
Article Synopsis
- HCoV-EMC is linked to severe pneumonia and has similarities to SARS-CoV in how it infects human airway cells.
- It prevents the activation of the antiviral response mediated by IRF-3, which normally leads to production of interferons.
- However, HCoV-EMC is more vulnerable to the antiviral effects of interferons compared to SARS-CoV.
The filoviral matrix protein VP40 orchestrates virus morphogenesis and budding. To do this it interacts with both the glycoprotein (GP1,2) and the ribonucleoprotein (RNP) complex components; however, these interactions are still not well understood. Here we show that for efficient VP40-driven formation of transcription and replication-competent virus-like particles (trVLPs), which contain both an RNP complex and GP1,2, the RNP components and VP40, but not GP1,2 and VP40, must be from the same genus.
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