Publications by authors named "Larissa Silva Souza"
Products derived from the latex of were obtained through hydrolysis and column chromatography, resulting in products rich in triterpenes, ingenol 3-esters (I3E), and other derivatives from hydrolysed latex. These products underwent evaluation for their cytotoxic activity against gastric adenocarcinoma cells (AGS). Triterpene derivatives were synthesised, and the selectivity of each product was assessed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the cytotoxic effects of ethanol extract from the aerial parts of a plant, traditionally used in Brazil for treating diseases, on gastric adenocarcinoma cells (AGS), as well as its chemical composition.
- Hexane and aqueous fractions of the extract displayed higher cytotoxicity against AGS cells, indicating potential effectiveness in cancer treatment.
- Key compounds identified include triterpenes like euphol and friedelin in the hexane fraction, and ellagic acid as the main phenolic compound in the aqueous extract, which are believed to contribute to the extract's antiproliferative effects against cancer cells.
Ethnopharmacological Relevance: Euphorbia tirucalli L. is widely used by Brazilian folk medicine, mainly for its anticancer activity. However, its commercialization was banned by The Brazilian National Sanitary Surveillance Agency (ANVISA) due to the presence of some compounds considered toxic, such as the diterpene esters.
View Article and Find Full Text PDFPost-analysis methods for lactate threshold depend on training intensity and aerobic capacity in runners. An experimental laboratory study.
Sao Paulo Med J
November 2015
Article Synopsis
- The study assessed different methods for determining lactate threshold in endurance runners with varying training levels (highly trained vs. lowly trained).
- Twenty-seven male runners underwent a treadmill test with blood lactate analysis to evaluate their thresholds using three methods: DT1, 4 mmol/l, and semi-log.
- Results showed that highly trained athletes had higher lactate thresholds, and the 4 mmol method yielded lower results compared to DT1 and semi-log, particularly in lowly trained runners.