Neuropsychological assessment after long-term omeprazole treatment.

Recent studies suggest that Omeprazole, a widely used treatment for gastric acid-related disorders, may have a significant effect on human cognition. However, there is no consensus on the matter. Though some studies suggest the drug is associated with an increased risk of cognitive decline, memory impairment, and dementia, this issue has not been sufficiently studied.

Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use.

Objectives: To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months.

Methods: A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.