Publications by authors named "Larissa Schaefer"
Article Synopsis
- The peritoneum, the largest organ next to the skin, plays a significant role in abdominal health, but research on its tight junctions and transport mechanisms remains limited.
- A study involving 93 participants assessed these structures in healthy individuals, those with chronic kidney disease (CKD), and patients undergoing peritoneal dialysis (PD) using advanced microscopy techniques.
- The findings highlighted age-related variations and changes in specific proteins associated with CKD and PD that affected transperitoneal transport rates of creatinine and glucose, suggesting potential for further experimental investigations.
Background And Objectives: COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.
Methods: This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection.
Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The barrier paracellular permeability depends on the composition and spatial distribution of the cell-to-cell tight junctions (TJ). Here, we provide an experimental workflow that yields several layers of physiological data in the setting of a single endothelial cell monolayer.
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