Publications by authors named "Larissa Natany"
Article Synopsis
- - The SaMi-Trop project is a study focused on chronic Chagas cardiomyopathy involving 1,959 patients in endemic areas of Brazil, with updates provided from their second cohort visit after two years.
- - Out of the original participants, 1,585 (about 80%) returned for the follow-up, revealing a mortality rate of 6.7%, which varied based on different clinical factors.
- - Improvements were noted in participants' quality of life, including fewer symptoms and increased medication usage, with better outcomes linked to lower NT-Pro-BNP levels and prior treatment with benznidazole.
Chagas cardiomyopathy (ChCM) is a severe consequence of Trypanosoma cruzi infection and has a range of electrocardiographic (ECG) and echocardiographic (ECHO) manifestations. There is a need for a standard and parsimonious research cardiac end point that does not rely on expert panel adjudication, and it is not intended to change the ChCM definition. We use data from the REDS-II cohort to propose a simplified cardiac endpoint.
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