Publications by authors named "Larissa Miwa Kikuchi Ochikubo"
Mol Microbiol
November 2024
Article Synopsis
- Fusarium spp., particularly Fusarium oxysporum, is identified as a key cause of onychomycosis (nail fungus) in healthy individuals, yet there's limited research on its biofilm formation and the role of signaling molecules.
- The study successfully detected a quorum sensing (QS) molecule, 2-ethyl-1-hexanol (2EH), in ex vivo biofilms on human nails and investigated its effects on biofilm in vitro.
- Results showed that synthetic 2EH enhanced biofilm growth by promoting filamentation and increasing extracellular matrix production, while decreasing proteins and nucleic acids, marking the first identification of 2EH's role as a QS molecule in Fusarium biofilms on nails.
