Hybrid near and far field electrospinning of PVDF-TrFE/BaTiOscaffolds: morphology and osteoblast-like cell responses.

Scaffolds are of great interest in tissue engineering associated with regenerative medicine owing to their ability to mimic biological structures and provide support for new tissue formation. Several techniques are used to produce biological scaffolds; among them, far-field electrospinning (FFES) process is widely used due to its versatility in producing promising structures similar to native tissues owing to the electrospun nanofibers. On the other hand, near-field electrospinning (NFES) has been investigated due to the possibility of creating scaffolds with suitable architecture for their use in specific biological tissues.

Mesenchymal Stem Cells Combined with a P(VDF-TrFE)/BaTiO Scaffold and Photobiomodulation Therapy Enhance Bone Repair in Rat Calvarial Defects.

Background: Tissue engineering and cell therapy have been the focus of investigations on how to treat challenging bone defects. This study aimed to produce and characterize a P(VDF-TrFE)/BaTiO scaffold and evaluate the effect of mesenchymal stem cells (MSCs) combined with this scaffold and photobiomodulation (PBM) on bone repair.

Methods And Results: P(VDF-TrFE)/BaTiO was synthesized using an electrospinning technique and presented physical and chemical properties suitable for bone tissue engineering.