Brasiliensic acid: cytotoxic and genotoxic, acute toxicity and pharmacological prediction of a new promising molecule.

Brasiliensic acid (Bras) is a chromanone isolated from Cambèss. bark extracts with confirmed potential activity on gastric ulcer and infection. This study aimed to investigate the and toxicity of Bras and molecular docking studies on its interactions with the ri virulence factors and selected gastric cancer-related proteins.

Diversity, geographical distribution, and prevalence of Entamoeba spp. in Brazil: a systematic review and meta-analysis.

The genus Entamoeba includes a variety of widely distributed species adapted to live in the digestive tracts of humans and a large variety of animals of different classes. The objective of this study was to investigate the prevalence, distribution, and molecular epidemiology of Entamoeba spp. in different classes of hosts in Brazil.

Evaluation of genotoxicity and subchronic toxicity of the standardized leaves infusion extract of Copaifera malmei Harms in experimental models.

Ethnopharmacological Relevance: Copaifera malmei Harms (Fabaceae), known mainly as óleo-mirim, is a native and endemic plant found in the states of Mato Grosso and Goiás of Brazil. The plant's leaves infusion is popularly used by riverine communities of the northern Araguaia microregion, Mato Grosso, Brazil, for the treatment of gastric ulcers and inflammatory diseases of the respiratory tract. The gastric antiulcer activity of the standardized leaves infusion extract of Copaifera malmei (SIECm) in rodents has been reported.

Evaluation of toxicity of Calophyllum brasiliense stem bark extract by in vivo and in vitro assays.

Ethnopharmacological Relevance: Calophyllum brasiliense Camb., Clusiaceae, is commonly known as "guanandi" and its stem bark is used in Brazilian traditional medicine to treat rheumatism, vein problems, hemorrhoids and gastric ulcers. The aim of this study was to evaluate the toxicity of hexane extract of Calophyllum brasiliense stem bark (HECb) using in vitro and in vivo experimental models.

Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb.

Ethnopharmacological Relevance: Calophyllum brasiliense Camb. (Clusiaceae), popularly known as 'guanandi', is found in the tropical areas and swampy lands. The latex exuding from its bark is used in the treatment of gastric ulcer in folk medicine.