Publications by authors named "Larissa L F de Sousa"

Background: Rabies, a lethal viral zoonotic disease, remains a significant global public health concern. In northeastern Brazil, in particular, its epidemiology is complex and dynamic, characterized by the presence of several reservoirs associated with human rabies infection.

Methods: This study, conducted from June 2022 to July 2023, was part of a passive epidemiological surveillance initiative under Brazil's National Rabies Surveillance Program.

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We detected an emerging human-associated gemykibivirus-2 (HuGkV-2) in rectal swab sample from Molossus molossus bat from Brazil. Phylogenetic analysis further revealed well-supported relationships between our sequence and those associated with human infections. This study underscores the necessity of ongoing monitoring of HuGkV-2 to elucidate potential spillback events, its role in human infections, and its public health implications.

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Article Synopsis
  • Human rabies is a deadly disease caused by lyssaviruses, and there has been an increase in cases following the COVID-19 pandemic.
  • A case from Ceará, Brazil in 2023 involved a patient bitten by a marmoset who was also co-infected with SARS-CoV-2, diagnosed using minimally invasive autopsy (MIA).
  • MIA is beneficial for its biosafety and efficiency, reducing body disfigurement and enhancing rabies diagnostics and family cooperation in tracking the disease.
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Rabies is a fatal viral zoonosis caused by rabies virus (RABV). RABV infects the central nervous system and triggers acute encephalomyelitis in both humans and animals. Endemic in the Brazilian Northeast region, RABV emergence in distinct wildlife species has been identified as a source of human rabies infection and as such, constitutes a public health concern.

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