Can we predict relapse in Graves' disease? Results from a systematic review and meta-analysis.

Background: Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options.

Purpose: We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD in patients with Graves' disease.

Methods: Based on a pre-specified protocol, we searched PubMed, EMBASE and Cochrane in July 2015 for case-control, controlled and randomized-controlled trials reporting risk factors for relapse after stopping ATD.

Does Immunosuppressive Therapy Improve Outcomes in Graves' Disease? A Systematic Review and Meta-Analysis.

Background: Whether the addition of immunosuppressive drugs to standard antithyroid drugs reduces the relapse risk in Graves' disease remains uncertain.

Purpose: The aim of this study was to investigate the effects of immunosuppressive drugs on the relapse rate after a first episode of hyperthyroidism due to Graves' disease.

Methods: Based on a pre-specified protocol, PubMed (1946-July 2015), EMBASE (1947-July 2015), and Cochrane (1992-July 2015) databases were searched.