Publications by authors named "Larisa J. Geskin"
Purpose: Denileukin diftitox (DD)-cxdl is a fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2. This phase III, multicenter, open-label, single-arm registrational trial evaluated the efficacy and safety of DD-cxdl in patients with relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL).
Patients And Methods: In the main study, which followed a dose-finding lead-in, DD-cxdl was administered intravenously daily (5 days; 9 µg/kg/d once daily) every 21 days for up to eight cycles.
Article Synopsis
- Regular use of OTC sunscreen is crucial for preventing skin cancer, but it is rarely covered by Medicaid plans across the U.S.
- A review of 111 Medicaid preferred drug lists revealed that only five states cover sunscreen, putting a financial burden on low-income individuals and families.
- The text analyzes the current Medicaid policies on sunscreen coverage and estimates the costs related to this essential skin cancer prevention method.
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). While MF generally follows an indolent course, a subset of patients will experience progressive and/or treatment-refractory disease; Sézary syndrome is an aggressive lymphoma associated with high morbidity and mortality. Although allogeneic hematopoietic cell transplant (allo-HCT) is the only currently available potentially curative treatment modality for MF/SS there is no published guidance on referral criteria, transplant timing orallo-HCT approach.
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- - The most common types of liposarcomas are well-differentiated and dedifferentiated liposarcomas, usually found in the deep retroperitoneum or extremities, while atypical lipomatous tumors (ALT) are rare and less studied when located superficially.
- - A case study of a 54-year-old man revealed an ALT on his left upper back that had unusual characteristics, including significant pleomorphism and specific gene amplifications, which sets it apart from typical ALT cases reported.
- - The report discusses the diagnostic process and histopathological findings of the tumor, while providing an overview of different liposarcoma subtypes and management strategies.
Article Synopsis
- There are currently no established maintenance protocols for cutaneous lymphomas, prompting a study to analyze treatments and outcomes during the COVID-19 pandemic.
- The research included data from 149 patients across nine international institutions, revealing younger patients tended to have earlier stages of the disease and more commonly received skin-directed therapies.
- Findings indicated that treatment interruptions were linked to disease progression and poorer outcomes, with patients experiencing interruptions twice as likely to progress compared to those who maintained their treatments, highlighting the importance of continuous maintenance therapies.
Article Synopsis
- Lichen sclerosus et atrophicus (LSA) is a chronic skin condition primarily affecting female genitalia, while morphea is a rare inflammatory skin disorder characterized by hard skin patches.
- There is an ongoing debate among researchers about whether LSA and morphea are related or separate conditions, particularly when they occur in the same patient.
- A case is reported involving a 62-year-old woman with both extragenital LSA-morphea overlap in her inguinal folds and subsequent development of genital LSA three months later, highlighting the rare progression between these two conditions that had not been previously documented.
Background: CELF2 belongs to the CELF RNA-binding protein family and exhibits antitumor activity in various tumor models. Analysis of the pan-cancer TCGA database reveals that CELF2 expression strongly correlates with favorable prognosis among cancer patients. The function of CELF2 in nonmelanoma skin cancer has not been studied.
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- Researchers investigated cases of lymphoproliferative disorders (LPDs) and cutaneous lymphomas that appeared after COVID-19 vaccination, examining the link between specific vaccines and these reactions.
- They found 50 biopsy-proven cases primarily from the U.S., Italy, and Greece, with the Pfizer-BioNTech vaccine associated with 72% of these instances.
- Most patients experienced favorable outcomes, with a common form being lymphomatoid papulosis, and treatment options varied from observational care to medication like steroids and methotrexate.
Article Synopsis
- Skin cancer mortality rates are on the rise, emphasizing the need for survival analysis to identify at-risk individuals and effective interventions.
- Current statistical methods struggle to integrate diverse data types (e.g., genetics, demographics) and predictive algorithms, limiting their effectiveness.
- Advances in AI, including supervised and unsupervised learning, hold promise for improving skin cancer survival analysis, though most studies focus on melanoma, indicating a need for broader research on various skin cancers and the combination of different data types.
The etiology of CTCL is a subject of extensive investigation. Researchers have explored links between CTCL and environmental chemical exposures, such as aromatic hydrocarbons (eg, pesticides and benzene), as well as infectious factors, including various viruses (eg, human T-lymphotropic virus [HTLV]-I and HTLV-II) and bacteria (eg, Staphylococcus aureus). There has been growing emphasis on the role of malignant inflammation in CTCL development.
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- Lymphomatoid papulosis (LyP) is a rare skin disorder affecting T-cells, and there's limited information about its impact on children.
- A study analyzed data from 87 pediatric patients diagnosed with LyP over a 24-year period, noting that most cases were initially misdiagnosed and the average age at onset was 7 years.
- The prognosis appears positive, with a 100% overall survival rate, although 10% of patients had associated blood cancers, indicating a significantly higher risk of malignancy compared to the general youth population.
Monoclonal Gammopathy of Undetermined Significance (MGUS) is a clonal plasma cell disorder that is considered preneoplastic, asymptomatic, and only requiring observation. However, MGUS may result in cutaneous complications, which are poorly understood, causing treatment delays and patient suffering. We present 30 patients with cutaneous findings associated with MGUS, characterizing clinical presentations, isoforms, treatments, and outcomes.
View Article and Find Full Text PDFTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the possible mechanisms underlying these reactions.
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- Mucha-Habermann disease (MHD) is an inflammatory skin condition with symptoms resembling cutaneous T-cell lymphoma, while its severe variant, febrile ulceronecrotic MHD (FUMHD), presents with systemic symptoms and ulcers.
- A case study of a 21-year-old woman showed atypical lymphomatoid features of FUMHD alongside hemophagocytic lymphohistiocytosis (HLH), leading to significant clinical findings and a biopsy that indicated atypical CD8 + lymphocyte infiltration.
- Treatment using etoposide and dexamethasone resulted in rapid improvement of her symptoms, with the patient's skin lesions healing over time and confirming the MHD diagnosis; she has remained
The field of dermatology is experiencing the rapid deployment of artificial intelligence (AI), from mobile applications (apps) for skin cancer detection to large language models like ChatGPT that can answer generalist or specialist questions about skin diagnoses. With these new applications, ethical concerns have emerged. In this scoping review, we aimed to identify the applications of AI to the field of dermatology and to understand their ethical implications.
View Article and Find Full Text PDFThe objective of this study is to describe survival outcomes in patients with metastatic melanoma in a real-world setting receiving combination and single-agent immunotherapy outside the clinical trial context. We conducted a retrospective single-institution study of patients with metastatic melanoma in a real-world setting. Survival was calculated using log-rank test.
View Article and Find Full Text PDFPatients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to treatment resistance. Here, we report that S aureus and staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used in CTCL. Supernatant from patient-derived, SE-producing S aureus and recombinant SE significantly inhibit cell death induced by histone deacetylase (HDAC) inhibitor romidepsin in primary malignant T cells from patients with SS.
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