Insights into Structure and Biological Activity of Copper(II) and Zinc(II) Complexes with Triazolopyrimidine Ligands.

In an attempt to increase the biological activity of the 1,2,4-triazolo[1,5-]pyrimidine scaffold through complexation with essential metal ions, the complexes -[Cu(mptp)Cl] (), [Zn(mptp)Cl(DMSO)] () (mptp: 5-methyl-7-phenyl-1,2,4-triazolo[1,5-]pyrimidine), [Cu(dmtp)Cl]·2HO () and [Zn(dmtp)Cl] () (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-]pyrimidine), were synthesized and characterized as new antiproliferative and antimicrobial species. Both complexes () and () crystallize in the 2/n monoclinic space group, with the tetrahedral surroundings generating a square-planar stereochemistry in the Cu(II) complex and a tetrahedral stereochemistry in the Zn(II) species. The mononuclear units are interconnected in a supramolecular network through π-π interactions between the pyrimidine moiety and the phenyl ring in () while supramolecular chains resulting from C-H∙∙∙π interactions were observed in ().

Nanofiltration Composite Membranes Based on KIT-6 and Functionalized KIT-6 Nanoparticles in a Polymeric Matrix with Enhanced Performances.

The nanofiltration composite membranes were obtained by incorporation of KIT-6 ordered mesoporous silica, before and after its functionalization with amine groups, into polyphenylene-ether-ether-sulfone (PPEES) matrix. The incorporation of silica nanoparticles into PPEES polymer matrix was evidenced by FTIR and UV-VIS spectroscopy. SEM images of the membranes cross-section and their surface topology, evidenced by AFM, showed a low effect of KIT-6 silica nanoparticles loading and functionalization.