Publications by authors named "Larisa Imamovic"
Background: Glioblastoma (GBM), the most common malignant brain tumor, is associated with devastating outcomes. IPAX-1 was a multicenter, open-label, single-arm phase I study to evaluate carrier-added 4--[I]iodo-phenylalanine ([I]IPA) plus external radiation therapy (XRT) in recurrent GBM.
Methods: A total of 10 adults with recurrent GBM who had received first-line debulking surgery plus radio-chemotherapy, were randomized to a single-dose regimen (1f; I-IPA 2 GBq before XRT); a fractionated parallel dose regimen (3f-p; 3 I-IPA 670 MBq fractions, in parallel with second-line XRT), or a fractionated sequential dose regimen (3f-s; 3 I-IPA 670 MBq fractions before and after XRT).
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors.
J Pathol Clin Res
March 2022
Article Synopsis
- Papillary thyroid carcinoma tall cell variant (PTC-TCV) is a more aggressive form of thyroid cancer that has similarities with another type called oncocytic tumors.
- Researchers studied 17 PTC-TCV samples and compared them to 16 regular PTC cases, checking for changes in their mitochondria, DNA mutations, and protein levels.
- The study found that PTC-TCV had many mitochondrial DNA mutations and changes in proteins related to energy production, showing a stronger link to oncocytic tumors than regular papillary thyroid cancer.
Purpose: In this prospective study we compared the accuracy of F-fluorocholine PET/CT with that of Tc-MIBI orTc-tetrofosmin SPECT/CT in the preoperative detection of parathyroid adenoma in patients with primary hyperparathyroidism. We also assessed the value of semiquantitative parameters in differentiating between parathyroid hyperplasia and adenoma.
Methods: Both F-fluorocholine PET/CT and Tc-MIBI/tetrofosmin SPECT/CT were performed in 100 consecutive patients with biochemical evidence of primary hyperparathyroidism.
Purpose: To prospectively evaluate the potential value of fluorocholine (FCH) positron emission tomography (PET)/computed tomography (CT) in the preoperative staging of patients with prostate cancer who had intermediate or high risk of extracapsular disease.
Materials And Methods: Institutional review board approval and written informed consent were obtained. Overall, 132 patients with prostate cancer (mean age, 63 years +/- 7 [standard deviation]) were enrolled between October 2003 and June 2008.